2019
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation
Abeler-Dörner L, Laing A, Lorenc A, Ushakov D, Clare S, Speak A, Duque-Correa M, White J, Ramirez-Solis R, Saran N, Bull K, Morón B, Iwasaki J, Barton P, Caetano S, Hng K, Cambridge E, Forman S, Crockford T, Griffiths M, Kane L, Harcourt K, Brandt C, Notley G, Babalola K, Warren J, Mason J, Meeniga A, Karp N, Melvin D, Cawthorne E, Weinrick B, Rahim A, Drissler S, Meskas J, Yue A, Lux M, Song-Zhao G, Chan A, Ballesteros Reviriego C, Abeler J, Wilson H, Przemska-Kosicka A, Edmans M, Strevens N, Pasztorek M, Meehan T, Powrie F, Brinkman R, Dougan G, Jacobs W, Lloyd C, Cornall R, Maloy K, Grencis R, Griffiths G, Adams D, Hayday A. High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature Immunology 2019, 21: 86-100. PMID: 31844327, PMCID: PMC7338221, DOI: 10.1038/s41590-019-0549-0.Peer-Reviewed Original ResearchConceptsHigh-throughput genetic screensImmune variationHigh-throughput phenotypingMouse gene knockoutsAssociated with immunocompetenceGenetic screeningLoss of functionContribution of geneticsPhysiological traitsGenetic resourcesGene knockoutIndividual immune parametersImmune parametersCorrelation networkPhenotypeImmunological structureTolerance to lossGenesHitsGeneticsStructural underpinningsTraitsKnockoutStructural perspectiveVariation
1987
Cloning of genes from members of the family Enterobacteriaceae with mini-Mu bacteriophage containing plasmid replicons
Groisman EA, Casadaban MJ. Cloning of genes from members of the family Enterobacteriaceae with mini-Mu bacteriophage containing plasmid replicons. Journal Of Bacteriology 1987, 169: 687-693. PMID: 3542967, PMCID: PMC211834, DOI: 10.1128/jb.169.2.687-693.1987.Peer-Reviewed Original ResearchConceptsSensitive recipient strainFamily EnterobacteriaceaeHigh phage titersC. freundiiProteus mirabilisPlasmid repliconsCitrobacter freundiiS. typhimuriumDrug-resistant transductantsSpecific mutationsMu derivativesE. coliSalmonella typhimuriumEnterobacteriaceaeFreundiiRecipient strainPhage titerTyphimuriumEscherichia coli bacteriophageInfectionTiters
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