2022
An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study
Geisen C, Kjaer M, Fleck E, Skogen B, Armstrong R, Behrens F, Bhagwagar Z, Braeuninger S, Mortberg A, Olsen K, Gastón Schäfer S, Walter C, Seifried E, Wikman A, Kjeldsen-Kragh J, Koehm M. An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study. Journal Of Thrombosis And Haemostasis 2022, 21: 838-849. PMID: 36696185, DOI: 10.1016/j.jtha.2022.11.041.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Human PlateletFemaleFetusHumansImmunoglobulin GInfant, NewbornIntegrin beta3MalePregnancySingle-Blind MethodThrombocytopenia, Neonatal AlloimmuneConceptsFetal/Neonatal Alloimmune ThrombocytopeniaNeonatal alloimmune thrombocytopeniaHPA-1aAlloimmune thrombocytopeniaHuman platelet antigen 1aTreatment-emergent adverse eventsPlacebo 1 hourHPA-1a antibodiesFNAIT casesHyperimmune IgGPrimary endpointAdverse eventsFetus/Healthy menSingle doseAntigen 1aHLA-A2Concept studyCohort 1PlaceboFlow cytometryThrombocytopeniaPlateletsAdministrationWeeks
2008
Acute vancomycin-dependent immune thrombocytopenia as an anamnestic response
Kenney B, Tormey CA. Acute vancomycin-dependent immune thrombocytopenia as an anamnestic response. Platelets 2008, 19: 379-383. PMID: 18791945, DOI: 10.1080/09537100802082280.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAmputation, SurgicalAnti-Bacterial AgentsAntigens, Human PlateletAutoantibodiesBacteremiaCeftazidimeDrug Therapy, CombinationFoot DiseasesGram-Positive Bacterial InfectionsHumansImmunoglobulin GImmunoglobulin MImmunologic MemoryMaleMiddle AgedPurpura, Thrombocytopenic, IdiopathicSurgical Wound InfectionVancomycinConceptsAntibiotic therapyPlatelet antibodiesPlatelet countPlatelet destructionAdverse bleeding eventsAnamnestic antibody responseDrug-related thrombocytopeniaNew onset thrombocytopeniaRapid platelet destructionAnti-platelet antibodiesNormal platelet countCases of thrombocytopeniaSafe drug useBleeding eventsVancomycin administrationWet gangreneImmune thrombocytopeniaImmediate discontinuationRare complicationMale patientsAnamnestic responseDrug withdrawalSevere thrombocytopeniaAcute reductionPrior sensitization
2001
Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass
Mathew J, Rinder C, Howe J, Fontes M, Crouch J, Newman M, Phillips-Bute B, Smith B, Group T. Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. The Annals Of Thoracic Surgery 2001, 71: 663-666. PMID: 11235724, DOI: 10.1016/s0003-4975(00)02335-3.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationPlA1/A1PlA1/A2Cardiopulmonary bypassNeurocognitive declinePlA2 polymorphismPlatelet GPIIIaState ExaminationBaseline Mini-Mental State ExaminationGreater neurocognitive declineProthrombotic genetic factorsPostoperative day 4Prothrombotic risk factorsEmbolic insultFrequent complicationPlA2 allelePlaque embolizationLocal thrombosisRisk factorsThrombotic processCardiovascular settingsPlA2 genotypeNeurocognitive changesDay 4Multivariate analysis
1995
Alloimmune thrombocytopenia: Fetal and neonatal losses related to cordocentesis
Paidas M, Berkowitz R, Lynch L, Lockwood C, Lapinski R, McFarland J, Bussel J. Alloimmune thrombocytopenia: Fetal and neonatal losses related to cordocentesis. American Journal Of Obstetrics And Gynecology 1995, 172: 475-479. PMID: 7856672, DOI: 10.1016/0002-9378(95)90559-6.Peer-Reviewed Original ResearchConceptsAlloimmune thrombocytopeniaExact testNeonatal lossAntenatal intracranial hemorrhageMean platelet countMulticenter treatment studyFisher's exact testResult of exsanguinationWilcoxon rank sum testRank sum testFatal exsanguinationIntracranial hemorrhageNeonatal deathPlatelet countCordocentesisTreatment studiesThrombocytopeniaFetusesUntreated siblingsLaboratory data
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