2023
RIG-I recognizes metabolite-capped RNAs as signaling ligands
Schweibenz B, Solotchi M, Hanpude P, Devarkar S, Patel S. RIG-I recognizes metabolite-capped RNAs as signaling ligands. Nucleic Acids Research 2023, 51: 8102-8114. PMID: 37326006, PMCID: PMC10450190, DOI: 10.1093/nar/gkad518.Peer-Reviewed Original ResearchConceptsRIG-IRNA endsRIG-I signaling pathwayIn vitro transcriptionRIG-I signalingDouble-stranded RNAInnate antiviral immune responseInterferon responseReceptor RIG-ICellular signaling assaysCapped RNACellular rolesPathogenic RNAsViral genomeEndogenous mRNAReplication intermediatesM7GSignaling ligandsImmune responseInnate immune receptor RIG-ISignaling pathwayRNASignaling assaysATPase activityAntiviral immune response
2022
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading
Schweibenz B, Devarkar S, Solotchi M, Craig C, Zheng J, Pascal B, Gokhale S, Xie P, Griffin P, Patel S. The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading. The EMBO Journal 2022, 41: embj2021109782. PMID: 35437807, PMCID: PMC9108607, DOI: 10.15252/embj.2021109782.Peer-Reviewed Original ResearchConceptsC-terminal domainNon-specific RNAHelicase domainRIG-IRIG-I C-terminal domainReceptor RIG-IRNA proofreadingRNA specificityHelicaseProofreading mechanismInnate immune receptor RIG-IRNAViral RNANovel targetProofreadingAberrant immune responseNegative charge regionViral infectionImmune responseHEL1Domain
2016
Structural and Mechanistic Basis for S elf versus Non‐self RNA discrimination by the Innate Immune Receptor RIG‐I
Devarkar S, Wang C, Ramanathan A, Jiang F, Miller M, Khan A, Marcotrigiano J, Patel S. Structural and Mechanistic Basis for S elf versus Non‐self RNA discrimination by the Innate Immune Receptor RIG‐I. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.592.3.Peer-Reviewed Original ResearchRIG-IM7GCap-0Cellular RNARIG-I signalingPost-transcriptional modificationsReceptor RIG-ICAP-1Cellular signaling responsesType I interferon responseNucleotide riboseRIG-I.RNA discriminationBiochemical characterizationAutoinhibitory interfaceCap structureRNA ligandsRNA selectionViral immune evasion mechanismsRNA affinityX-ray crystallographyInnate immune receptor RIG-IEnd modificationSelf-RNABlunt end
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