Structural and Mechanistic Basis for S elf versus Non‐self RNA discrimination by the Innate Immune Receptor RIG‐I
Devarkar S, Wang C, Ramanathan A, Jiang F, Miller M, Khan A, Marcotrigiano J, Patel S. Structural and Mechanistic Basis for S elf versus Non‐self RNA discrimination by the Innate Immune Receptor RIG‐I. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.592.3.Peer-Reviewed Original ResearchRIG-IM7GCap-0Cellular RNARIG-I signalingPost-transcriptional modificationsReceptor RIG-ICAP-1Cellular signaling responsesType I interferon responseNucleotide riboseRIG-I.RNA discriminationBiochemical characterizationAutoinhibitory interfaceCap structureRNA ligandsRNA selectionViral immune evasion mechanismsRNA affinityX-ray crystallographyInnate immune receptor RIG-IEnd modificationSelf-RNABlunt end
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