2022
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading
Schweibenz B, Devarkar S, Solotchi M, Craig C, Zheng J, Pascal B, Gokhale S, Xie P, Griffin P, Patel S. The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading. The EMBO Journal 2022, 41: embj2021109782. PMID: 35437807, PMCID: PMC9108607, DOI: 10.15252/embj.2021109782.Peer-Reviewed Original ResearchConceptsC-terminal domainNon-specific RNAHelicase domainRIG-IRIG-I C-terminal domainReceptor RIG-IRNA proofreadingRNA specificityHelicaseProofreading mechanismInnate immune receptor RIG-IRNAViral RNANovel targetProofreadingAberrant immune responseNegative charge regionViral infectionImmune responseHEL1Domain
2002
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
Kang DC, Gopalkrishnan RV, Wu Q, Jankowsky E, Pyle AM, Fisher PB. mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 637-642. PMID: 11805321, PMCID: PMC117358, DOI: 10.1073/pnas.022637199.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAmino Acid SequenceAnimalsApoptosisCell DifferentiationCell DivisionCloning, MolecularDEAD-box RNA HelicasesDNA, ComplementaryGrowth InhibitorsHumansInterferon Type IInterferon-Induced Helicase, IFIH1MelanomaMolecular Sequence DataRecombinant ProteinsRNA HelicasesRNA, Double-StrandedSequence Homology, Amino AcidTumor Cells, CulturedTumor Stem Cell AssayConceptsRNA-dependent ATPase activityCaspase recruitment domainHelicase motifsHuman melanoma cellsRecruitment domainRNA helicase motifsRNA-dependent ATPaseMDA-5RNA helicase domainPutative RNA helicaseMelanoma cellsEarly response genesATPase activityProtein kinase C activationGrowth-suppressive propertiesMelanoma differentiation-associated gene 5Appropriate pharmacological manipulationKinase C activationHypothetical proteinsRNA helicaseHelicase domainDifferentiation-associated gene 5Mediator of IFNSubtraction hybridizationMda-5 expression
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