2023
RIG-I recognizes metabolite-capped RNAs as signaling ligands
Schweibenz B, Solotchi M, Hanpude P, Devarkar S, Patel S. RIG-I recognizes metabolite-capped RNAs as signaling ligands. Nucleic Acids Research 2023, 51: 8102-8114. PMID: 37326006, PMCID: PMC10450190, DOI: 10.1093/nar/gkad518.Peer-Reviewed Original ResearchConceptsRIG-IRNA endsRIG-I signaling pathwayIn vitro transcriptionRIG-I signalingDouble-stranded RNAInnate antiviral immune responseInterferon responseReceptor RIG-ICellular signaling assaysCapped RNACellular rolesPathogenic RNAsViral genomeEndogenous mRNAReplication intermediatesM7GSignaling ligandsImmune responseInnate immune receptor RIG-ISignaling pathwayRNASignaling assaysATPase activityAntiviral immune response
2016
Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I
Devarkar S, Wang C, Miller M, Ramanathan A, Jiang F, Khan A, Patel S, Marcotrigiano J. Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 596-601. PMID: 26733676, PMCID: PMC4725518, DOI: 10.1073/pnas.1515152113.Peer-Reviewed Original ResearchConceptsCap-0M7G capG capRetinoic acid-inducible gene ICAP-1Single-stranded RNAMechanisms of hostCapped RNAHigh-affinity bindingType I IFN responseNucleotide riboseRIG-I.Gene ICap structureRNA affinityM7GStructural basisSelf-RNARNAViral immune evasionATPase activitySignaling activityStructural insightsConformational changesDsRNA
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