2009
Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia
Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, Sherwin RS. Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia. Diabetes 2009, 58: 1237-1244. PMID: 19223595, PMCID: PMC2671041, DOI: 10.2337/db08-1557.Peer-Reviewed Original ResearchConceptsType 1 diabetic subjectsMedium-chain triglyceridesSynaptic transmissionDiabetic subjectsMedium-chain triglyceride ingestionType 1 diabetic patientsRat hippocampal slice preparationHippocampal synaptic transmissionBeta-hydroxybutyrate levelsType 1 diabetesHypoglycemic clamp studiesHippocampal slice preparationControl glucose concentrationsTriglyceride ingestionDiabetic patientsFatty acidsAcute hypoglycemiaSymptomatic responseHippocampal slicesSlice preparationFree fatty acidsGlucose levelsClamp studiesTherapeutic advantageNeuronal activity
1987
Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus
Poolos N, Mauk M, Kocsis J. Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus. Journal Of Neurophysiology 1987, 58: 404-416. PMID: 3655875, DOI: 10.1152/jn.1987.58.2.404.Peer-Reviewed Original ResearchConceptsEnd of stimulationConduction velocityRepetitive stimulationCA1 afferentsStratum radiatumCA1 regionPostsynaptic elementsPostsynaptic activityBiphasic changeRat hippocampal slice preparationCompound action potentialHippocampal slice preparationCharacteristic field potentialHigher stimulation frequenciesPostsynaptic modulationPresynaptic volleyKynurenic acidPyramidal cellsSlice preparationPresynaptic axonsPresynaptic excitabilitySynaptic transmissionConduction blockIon-sensitive microelectrodesPostsynaptic activation
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