2011
The tammar wallaby major histocompatibility complex shows evidence of past genomic instability
Siddle H, Deakin J, Coggill P, Wilming L, Harrow J, Kaufman J, Beck S, Belov K. The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics 2011, 12: 421. PMID: 21854592, PMCID: PMC3179965, DOI: 10.1186/1471-2164-12-421.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsChromosomes, Artificial, BacterialEvolution, MolecularExpressed Sequence TagsGene DuplicationGenes, MHC Class IIGenomic InstabilityMacropodidaeMajor Histocompatibility ComplexMaleMolecular Sequence DataMultigene FamilyPhylogenyPhysical Chromosome MappingSequence AlignmentSequence Analysis, DNAConceptsGene organizationMajor histocompatibility complexGenomic instabilityEutherian mammalsBackgroundThe major histocompatibility complexRetroviral elementsAustralian marsupialsMajor histocompatibility complex regionMajor histocompatibility complex genesGroup of genesClass III genesUnique model organismEndogenous retroviral elementsClass II regionBAC clonesGene evolutionClass II genesChromosome 2qGene familyHistocompatibility complexIII genesModel organismsProcessing genesMHC regionNon-mammalsEvidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia
Bajaj R, Xu F, Xiang B, Wilcox K, DiAdamo AJ, Kumar R, Pietraszkiewicz A, Halene S, Li P. Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia. Molecular Cytogenetics 2011, 4: 3. PMID: 21251322, PMCID: PMC3031273, DOI: 10.1186/1755-8166-4-3.Peer-Reviewed Original ResearchArray comparative genomic hybridizationCopy number alterationsAcute myeloid leukemiaClonal chromosomal abnormalitiesOligonucleotide array comparative genomic hybridizationGene contentBAC clonesEvidence-based approachComparative genomic hybridizationElderly patientsGenomic analysisGenomic contentDerivative chromosome 6Genomic featuresIsodicentric X chromosomeMyelodysplastic syndromeX chromosomeMyeloid leukemiaConclusionsOur dataCytogenomic analysisChromosome 6Clinical validitySegmental amplificationMYC geneClonal abnormalities
2007
Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules
Liao S, Bentley K, Lebrun M, Lesslauer W, Ruddle FH, Ruddle NH. Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 4577-4582. PMID: 17360566, PMCID: PMC1838643, DOI: 10.1073/pnas.0700334104.Peer-Reviewed Original ResearchConceptsDNA fragmentsTertiary lymphoid organsExpression of reporterEndogenous gene expressionBAC DNA fragmentsTissue-specific expressionBeta-galactosidase reporter geneHomologous recombination techniquesLymphoid organsLymphoid tissueEffector genesBAC clonesEndogenous genesRegulatory sequencesNasal-associated lymphoid tissueReporter geneGene expressionLacZ constructLTbetaR-Ig treatmentExon IIHEV-like vesselsGenesHigh endothelial venulesMolecular natureRecombination techniques
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