2008
Effects of 4′-chlorodiazepam on cellular excitation–contraction coupling and ischaemia–reperfusion injury in rabbit heart
Brown DA, Aon MA, Akar FG, Liu T, Sorarrain N, O’Rourke B. Effects of 4′-chlorodiazepam on cellular excitation–contraction coupling and ischaemia–reperfusion injury in rabbit heart. Cardiovascular Research 2008, 79: 141-149. PMID: 18304929, PMCID: PMC2562874, DOI: 10.1093/cvr/cvn053.Peer-Reviewed Original ResearchConceptsIschaemia-reperfusion injuryExcitation-contraction couplingReperfusion arrhythmiasRabbit heartsDose-dependent negative inotropic responseCellular excitation-contraction couplingPost-ischemic cardiac dysfunctionOnset of reperfusionMin of reperfusionSingle bolus doseNegative inotropic responseIschaemia/reperfusionIntracellular calcium transientsSarcolemmal ion channelsIsolated rabbit cardiomyocytesIon channelsCardiac action potentialContractile impairmentCardiac dysfunctionBolus doseContractile dysfunctionInotropic responseGlobal ischaemiaVoltage clamp methodCalcium current
1994
ATP gated potassium channels in acute myocardial hibernation and reperfusion
Offstad J, Kirkebøen K, Ilebekk A, Downing S. ATP gated potassium channels in acute myocardial hibernation and reperfusion. Cardiovascular Research 1994, 28: 872-880. PMID: 7923294, DOI: 10.1093/cvr/28.6.872.Peer-Reviewed Original ResearchConceptsVentricular systolic pressureLeft ventricular systolic pressurePerfusion-contraction matchingLow-flow ischaemiaSystolic pressurePiglet heartsPerfusion pressureIsolated rabbit heartRabbit heartsKATP channelsFlow ischaemiaRed blood cellsH reperfusionCoronary flowAcute hibernationKATP channel antagonist glibenclamideCoronary blood flow regulationBlood cellsPotassium channelsChannel antagonist glibenclamideEffects of aprikalimKATP channel modulationCoronary vascular toneAdenosine receptor blockadeAdenosine receptor antagonism
1992
Isolation and characterization of rabbit cardiac endothelial cells: Response to cyclic strain and growth factors in vitro
Widmann M, Letsou G, Phan S, Baldwin J, Sumpio B. Isolation and characterization of rabbit cardiac endothelial cells: Response to cyclic strain and growth factors in vitro. Journal Of Surgical Research 1992, 53: 331-334. PMID: 1405613, DOI: 10.1016/0022-4804(92)90057-7.Peer-Reviewed Original ResearchConceptsRetina-derived growth factorCardiac endothelial cellsEndothelial cellsGrowth factorPure endothelial cellsEC proliferationProliferative responseExogenous growth factorsTrophic effectsRabbit heartsAcetylated LDLCardiac endotheliumCollagenase digestionFetal bovine serumPulsatile strainSignificant increaseBovine serumProliferationEC morphologyCellsRegimenResponseLDLEndotheliumFactors
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