2023
Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD
Lewis C, Tafur J, Spencer S, Green J, Harrison C, Kelmendi B, Rabin D, Yehuda R, Yazar-Klosinski B, Cahn B. Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD. Frontiers In Psychiatry 2023, 14: 959590. PMID: 36815187, PMCID: PMC9939628, DOI: 10.3389/fpsyt.2023.959590.Peer-Reviewed Original ResearchPost-traumatic stress disorderSevere post-traumatic stress disorderTreatment responseClinical trialsRecent phase 3 clinical trialsPhase 3 clinical trialsClinician-Administered PTSD ScaleParent clinical trialKey HPA axis genesHPA axis genesPTSD symptom improvementGlucocorticoid receptor geneFalse discovery rate correctionAdrenal genesPlacebo groupSymptom improvementLarge cohortMethylation changesEpigenetic changesSymptom reductionPTSD ScaleTherapyHPA genesStress disorderPilot study
2021
Binge drinking following residential treatment for posttraumatic stress disorder among veterans with and without alcohol use disorder
Meshberg-Cohen S, Gross GM, Kachadourian LK, Harpaz-Rotem I. Binge drinking following residential treatment for posttraumatic stress disorder among veterans with and without alcohol use disorder. Journal Of Psychiatric Research 2021, 143: 202-208. PMID: 34500350, DOI: 10.1016/j.jpsychires.2021.09.024.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMilitary sexual traumaAlcohol use disorderPTSD symptom improvementResidential treatmentBinge drinkingStress disorderPTSD symptom changeResidential PTSD treatmentPTSD symptom decreaseUse disordersBinge drinking daysAlcohol-related variablesPTSD treatmentTrauma typesSexual traumaProblematic drinkingCombat exposureDrinking outcomesSymptom changeGreater likelihoodSymptom improvementBingeSymptom decreaseAlcohol use
2020
Courses of suicidal ideation among military veterans in residential treatment for posttraumatic stress disorder
Smith NB, Sippel LM, Rozek DC, Spangler PT, Traber D, Straud CL, Hoff R, Harpaz‐Rotem I. Courses of suicidal ideation among military veterans in residential treatment for posttraumatic stress disorder. Depression And Anxiety 2020, 37: 273-284. PMID: 31951318, PMCID: PMC7054126, DOI: 10.1002/da.22993.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderBaseline posttraumatic stress disorderPTSD treatmentResidential PTSD treatmentPhysical functioningSuicidal thoughtsStress disorderPTSD symptomsSubstance useVeterans Affairs medical facilitiesWorse physical functioningLength of stayPTSD symptom improvementTrauma-focused psychotherapySpecific treatment interventionsPTSD symptom changeSeverity of suicidalSI onsetRace/ethnicitySymptom improvementPTSD improvementBaseline depressionMultinomial logistic regressionTreatment interventionsSuicidal ideation
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