2018
A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea
Carr ZJ, Vells B, Wood BR, Lowery JD, Rogers AM, Kunselman AA, Karamchandani K, Vaida SJ. A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea. Medicine 2018, 97: e12585. PMID: 30278569, PMCID: PMC6181597, DOI: 10.1097/md.0000000000012585.Peer-Reviewed Original ResearchMeSH KeywordsAgedAirway ExtubationAnesthesia Recovery PeriodAnesthesia, GeneralBenzhydryl CompoundsBlood PressureDouble-Blind MethodFemaleHumansLength of StayMaleMiddle AgedModafinilPilot ProjectsPreoperative PeriodProof of Concept StudyRespiratory RateSleep Apnea, ObstructiveWakefulness-Promoting AgentsConceptsObstructive sleep apneaGeneral anesthesiaFunctional recoverySleep apneaPrimary outcomePACU lengthPsychomotor stimulantsPost-anesthesia care unit lengthDiagnosis of OSAIntraoperative bispectral index valuePlacebo-controlled pilot studyPost-anesthesia care unitPilot studyPostoperative pain scoresPost-anesthesia recoveryBispectral index valuesModafinil groupPain scoresSurgical populationNarcotic consumptionArterial pressureDaytime somnolenceCare unitAnesthesiaVolatile anesthetics
2001
Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine
Zachariou V, Caldarone B, Weathers-Lowin A, George T, Elsworth J, Roth R, Changeux J, Picciotto M. Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine. Neuropsychopharmacology 2001, 24: 576-589. PMID: 11282258, DOI: 10.1016/s0893-133x(00)00224-4.Peer-Reviewed Original ResearchConceptsPlace preferenceDA turnoverLow doseHigh-affinity nicotinic acetylcholine receptorsMesolimbic DA systemHigh-affinity nAChRsNicotinic antagonist mecamylamineWild-type miceMesolimbic dopamine systemFos-related antigensProperties of nicotineCocaine place preferenceΒ2 subunitNicotinic acetylcholine receptorsAntagonist mecamylamineDA releaseMetabolite DOPACNeurochemical changesSubthreshold doseType miceDopamine systemPsychomotor stimulantsAcetylcholine receptorsHigh dosesBrain regions
1999
Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization
Taylor J, Horger B. Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization. Psychopharmacology 1999, 142: 31-40. PMID: 10102780, DOI: 10.1007/s002130050859.Peer-Reviewed Original ResearchConceptsIntra-accumbens amphetamineIntra-NAc amphetamineCocaine sensitizationLocomotor sensitizationNucleus accumbensCR leverLong-term neuronal adaptationsSaline-treated groupMesolimbic dopamine systemStimulant drug useSaline infusionSaline injectionDopamine systemPsychomotor stimulantsDrug useNeuronal adaptationConditioned rewardStimulant drugsAmphetaminePrior exposureSensitizationTest daySeparate groupsNCR leverPredictive associations
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