2022
Epigenetics of alcohol-related liver diseases
Habash N, Sehrawat T, Shah V, Cao S. Epigenetics of alcohol-related liver diseases. JHEP Reports 2022, 4: 100466. PMID: 35462859, PMCID: PMC9018389, DOI: 10.1016/j.jhepr.2022.100466.Peer-Reviewed Original ResearchAlcohol-related liver diseaseLiver diseaseMajor public health problemChronic liver diseasePublic health problemProinflammatory roleSignificant morbidityMultiple disease statesHealth problemsDisease statesDiseaseClinical applicationNon-coding RNADiagnosisEpigenetic alterationsPrimary causeCurrent knowledgeEpigenetic changesReview articleStudy of epigeneticsHepatologistsMorbidityComplicationsChemokinesPathophysiology
2013
BRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling
Chaiyachati BH, Jani A, Wan Y, Huang H, Flavell R, Chi T. BRG1‐mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling. The EMBO Journal 2013, 32: 395-408. PMID: 23321680, PMCID: PMC3567501, DOI: 10.1038/emboj.2012.350.Peer-Reviewed Original ResearchConceptsTreg activationRegulatory T cellsSeverity of inflammationChemokine receptor genesT-cell lineageΑβ T cell lineagesCD4 cellsSuppress autoimmunityProinflammatory roleImmune toleranceFatal inflammationT cellsInflammatory cuesTregsInflammationBrg1 deletionReceptor geneChromatin-remodelling factor BRG1Activation levelsActivationCell lineagesTarget genesATPase activityPoint mutationsCells
2011
A Proinflammatory Role for Interleukin-22 in the Immune Response to Hepatitis B Virus
Zhang Y, Cobleigh MA, Lian J, Huang C, Booth CJ, Bai X, Robek MD. A Proinflammatory Role for Interleukin-22 in the Immune Response to Hepatitis B Virus. Gastroenterology 2011, 141: 1897-1906. PMID: 21708106, PMCID: PMC3199295, DOI: 10.1053/j.gastro.2011.06.051.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAnimalsCase-Control StudiesDisease Models, AnimalFemaleHepatitis BHepatitis B virusHepatitis B, ChronicHumansImmunity, InnateInterferon-gammaInterleukinsLiverMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicSeverity of Illness IndexTh17 CellsVirus ReplicationConceptsHepatitis B virusHBV transgenic miceIL-22Transgenic miceHBV infectionB virusT cellsImmune responseProinflammatory genesHBV-specific cytotoxic T cellsAntigen-nonspecific inflammatory cellsIL-22-induced expressionVirus replicationAcute HBV infectionSubsequent liver damageCytotoxic T cellsCytokine-based therapiesTh17 cellsLiver inflammationProinflammatory roleInflammatory cellsLiver damagePeripheral bloodSingle doseInflammatory response
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