2021
Erythroid enucleation: a gateway into a “bloody” world
Menon V, Ghaffari S. Erythroid enucleation: a gateway into a “bloody” world. Experimental Hematology 2021, 95: 13-22. PMID: 33440185, PMCID: PMC8147720, DOI: 10.1016/j.exphem.2021.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBirdsCalciumCell NucleusChromatinColony-Forming Units AssayComputational BiologyCytokinesCytoskeletal ProteinsDNA-Binding ProteinsErythroblastsErythrocytesErythropoiesisIntercellular Signaling Peptides and ProteinsMammalsMiceMicroRNAsProto-Oncogene ProteinsReceptors, Thyroid HormoneRepressor ProteinsReticulocytesrho GTP-Binding ProteinsTranscription FactorsTransport VesiclesYolk SacConceptsTerminal erythroid maturationFormation of reticulocytesEnucleation processHematopoietic stem cellsTranscription factorsCytoskeletal proteinsErythroid maturationFascinating processOrthochromatic erythroblastsTerminal maturationRate-limiting stepStem cellsIntricate processMaturationRed blood cellsCellsRBC productionMicroRNAsProteinProduction ex vivoErythroblastsEx vivoMechanismDaily productionProduction
2020
Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6+B helper T cells in systemic lupus erythematosus
Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, Mazzara S, Ranzani V, Rottoli E, Curti S, Penatti A, Karnani B, Kobayashi Y, Crosti M, Bombaci M, van Hamburg JP, Rossetti G, Gualtierotti R, Gerosa M, Gatti S, Torretta S, Pignataro L, Tas SW, Abrignani S, Pagani M, Grassi F, Meroni PL, Flavell RA, Geginat J. Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6+B helper T cells in systemic lupus erythematosus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 7305-7316. PMID: 32184325, PMCID: PMC7132288, DOI: 10.1073/pnas.1917834117.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusHelper T cellsT cellsIL-10Pathogenic roleSLE patientsLupus erythematosusIL-7RB cellsPathogenic anti-dsDNA antibodiesFollicular helper T cellsAnti-dsDNA antibodiesLupus-like diseaseT cell populationsB cell responsesProduction ex vivoCytokine reporter miceProminent pathogenic roleImmunoglobulin G productionNaïve B cellsIL-17Antiinflammatory cytokinesLymph nodesInterleukin-10Peripheral blood
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