2025
The mutagenic forces shaping the genomes of lung cancer in never smokers
Díaz-Gay M, Zhang T, Hoang P, Leduc C, Baine M, Travis W, Sholl L, Joubert P, Khandekar A, Zhao W, Steele C, Otlu B, Nandi S, Vangara R, Bergstrom E, Kazachkova M, Pich O, Swanton C, Hsiung C, Chang I, Wong M, Leung K, Sang J, McElderry J, Hartman C, Colón-Matos F, Miraftab M, Saha M, Lee O, Jones K, Gallego-García P, Yang Y, Zhong X, Edell E, Santamaría J, Schabath M, Yendamuri S, Manczuk M, Lissowska J, Świątkowska B, Mukeria A, Shangina O, Zaridze D, Holcatova I, Mates D, Milosavljevic S, Kontic M, Bossé Y, Rothberg B, Christiani D, Gaborieau V, Brennan P, Liu G, Hofman P, Yang L, Nowak M, Shi J, Rothman N, Wedge D, Homer R, Yang S, Pesatori A, Consonni D, Lan Q, Zhu B, Chanock S, Choi J, Alexandrov L, Landi M. The mutagenic forces shaping the genomes of lung cancer in never smokers. Nature 2025, 644: 133-144. PMID: 40604281, DOI: 10.1038/s41586-025-09219-0.Peer-Reviewed Original ResearchConceptsExposure to secondhand smokeExposure to second-hand tobacco smokeSecond-hand tobacco smokeHighest prevalenceLung cancerSecondhand smokeTP53 mutationsNever smokersLevels of air pollutionAir pollution levelsTobacco smokeAir pollutionTreatment-naive individualsPrevalence of eGFRSmokersDose-response effectEGFR mutationsSmokingCancer genomesEast AsiaKRAS mutationsDriver mutationsSomatic mutationsAdenocarcinomaCancer
2023
A quality improvement intervention to decrease the decline in renal function in pediatric liver transplant recipients
Batsis I, Elisofon S, Ferguson M, Jonas M, Kimball B, Lee C, Mitchell P, Fawaz R. A quality improvement intervention to decrease the decline in renal function in pediatric liver transplant recipients. Pediatric Transplantation 2023, 27: e14506. PMID: 36938904, DOI: 10.1111/petr.14506.Peer-Reviewed Original ResearchConceptsPrevalence of eGFRPost-intervention periodPediatric liver transplant recipientsYear post-LTLiver transplant recipientsChronic kidney diseasePost-LTTransplant recipientsSignificant non-modifiable risk factorNon-modifiable risk factorsChildren post-LTLong-term morbidityBlood pressure percentilesGlomerular filtration rateQuality improvement interventionsQuality improvement projectHospital dischargeRenal functionMonth 24Kidney diseaseFiltration rateRisk factorsInclusion criteriaQI interventionsMetabolic disorders
2019
Normality data of eGFR and validity of commonly used screening tests for CKD in an area with endemic CKD of unknown etiology; need for age and sex based precise cutoff values
Herath N, Dassanayake R, Dissanayake M, Janitha C, Weerakoon K, Kumarasinghe C, de Silva TG, Agampodi S. Normality data of eGFR and validity of commonly used screening tests for CKD in an area with endemic CKD of unknown etiology; need for age and sex based precise cutoff values. BMC Nephrology 2019, 20: 298. PMID: 31382902, PMCID: PMC6683421, DOI: 10.1186/s12882-019-1477-9.Peer-Reviewed Original ResearchConceptsScreening testMean eGFRRenal functionCreatinine ratioGlobal public health problemBackgroundChronic kidney diseaseBurden of CKDPrevalence of eGFRReduction of eGFRSex-specific cutUrine dipstick testHigh disease burdenPublic health problemResultsThe study sampleSulfosalicylic acid testProportion of peopleCause of majorityLower eGFRUrine albuminKidney diseaseMean agePrecise cutoff valuesUnknown etiologyUrine proteinDisease burden
2017
Clinically significant mutations in HIV-infected patients with lung adenocarcinoma
Thaler J, Sigel C, Beasley MB, Wisnivesky J, Crothers K, Bauml J, Hysell K, Emu B, Borsu L, Sigel K. Clinically significant mutations in HIV-infected patients with lung adenocarcinoma. British Journal Of Cancer 2017, 117: 1392-1395. PMID: 28934759, PMCID: PMC5672933, DOI: 10.1038/bjc.2017.333.Peer-Reviewed Original ResearchConceptsPrevalence of eGFRHIV statusKRAS mutationsLung adenocarcinomaMutation statusLung adenocarcinoma patientsPresence of KRASUninfected comparatorsOverall survivalAdenocarcinoma patientsTumor EGFRLung cancerMutational testingPatientsMajor causeEGFRPrevalenceGenetic alterationsHIVAdenocarcinomaSignificant mutationsStatusSurvivalMutationsSubjects
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