2025
A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
Wang J, Liu Y, Li H, Nguyen T, Soto-Vargas J, Wilson R, Wang W, Lam T, Zhang C, Lin C, Lewis D, Glausier J, Holtzheimer P, Friedman M, Williams K, Picciotto M, Nairn A, Krystal J, Duman R, Young K, Zhao H, Girgenti M. A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder. Genome Medicine 2025, 17: 43. PMID: 40301990, PMCID: PMC12042318, DOI: 10.1186/s13073-025-01473-1.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderDorsolateral prefrontal cortexPsychiatric disordersAutism spectrum disorderPrefrontal cortexDepressive disorderStress disorderGamma-aminobutyric acidGenome-wide association studiesPTSD brainsGenome-wide measurementsStudies of postmortem brainsSubgenual prefrontal cortexDisabling psychiatric disorderMultiple psychiatric disordersPrefrontal cortical areasPTSD casesHuman brain studiesBrain regionsSpectrum disorderGABAergic processesPostmortem brainsMDDProtein co-expression modulesProteomic profiling
2022
The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion
Arnsten A, Joyce M, Roberts A. The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion. Neuroscience & Biobehavioral Reviews 2022, 145: 105000. PMID: 36529312, PMCID: PMC9898199, DOI: 10.1016/j.neubiorev.2022.105000.Peer-Reviewed Original ResearchConceptsCortical pathwaysStress exposureDendritic spine lossChronic stress exposureAnti-depressant treatmentDeep brain stimulationPrefrontal cortical areasExcessive dopamineNeuromodulatory treatmentSSRI medicationNorepinephrine releaseSpine lossSubgenual cingulateCortical areasBrain stimulationChronic stressBA25MedicationsDorsolateral PFCTreatmentExposurePsychic painPainKetamineSymptoms
2017
Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field
Ide JS, Tung HC, Yang CT, Tseng YC, Li CR. Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field. Frontiers In Human Neuroscience 2017, 11: 222. PMID: 28522966, PMCID: PMC5415556, DOI: 10.3389/fnhum.2017.00222.Peer-Reviewed Original ResearchGray matter volumeGray matter concentrationPeripheral visual fieldOccipital cortexBarratt impulsivityVisual fieldYoung adultsPrefrontal cortical areasParietal-occipital cortexHigher impulsivity scoresMotor subscoresCortical volumeCortical areasMatter volumeCerebral structuresHealthy adultsClinical importanceHealthy populationNeuropsychiatric conditionsFrontal dysfunctionAlcohol useImpulsive individualsAdultsImpulsivity scoresNeural correlates
1989
Regional differences in the distribution of muscarinic cholinergic receptors in the macaque cerebral cortex
Lidow M, Gallager D, Rakic P, Goldman‐Rakic P. Regional differences in the distribution of muscarinic cholinergic receptors in the macaque cerebral cortex. The Journal Of Comparative Neurology 1989, 289: 247-259. PMID: 2808765, DOI: 10.1002/cne.902890206.Peer-Reviewed Original ResearchConceptsM2 receptor subtypeMuscarinic cholinergic receptorsReceptor subtypesCholinergic receptorsM2 receptorsCerebral cortexM1 receptorsLaminar distributionOccipital lobeM1 receptor subtypePopulation of M1Primary motor cortexPrefrontal cortical areasMacaque cerebral cortexCholinergic markersMotor cortexMuscarinic receptorsSupragranular layersLayer IVCortical areasNeocortical areasFrontal lobeCytoarchitectonic areasCortical layersCortical regions
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