2024
Pre-emptive therapeutic decisions based on measurable residual disease status in acute myeloid leukemia: ready for prime time?
El Chaer F, Perissinotti A, Loghavi S, Zeidan A. Pre-emptive therapeutic decisions based on measurable residual disease status in acute myeloid leukemia: ready for prime time? Leukemia 2024, 39: 1-7. PMID: 39496917, DOI: 10.1038/s41375-024-02458-6.Peer-Reviewed Original ResearchAcute myeloid leukemiaMyeloid leukemiaCore binding factor acute myeloid leukemiaIncreased risk of relapseResidual disease statusPost-allo-HCTHematopoietic cell transplantationRisk of relapseTherapeutic decision-makingInnovative treatment strategiesMRD-positiveIntensive chemotherapyMRD monitoringCell transplantationNPM1 mutationsImprove patient outcomesRisk stratificationTherapeutic decisionsTreatment strategiesIncreased riskRisk factorsMRDNatural historyPreemptive interventionAssess disease
2021
Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism
Whitehouse A, Varcin K, Pillar S, Billingham W, Alvares G, Barbaro J, Bent C, Blenkley D, Boutrus M, Chee A, Chetcuti L, Clark A, Davidson E, Dimov S, Dissanayake C, Doyle J, Grant M, Green C, Harrap M, Iacono T, Matys L, Maybery M, Pope D, Renton M, Rowbottam C, Sadka N, Segal L, Slonims V, Smith J, Taylor C, Wakeling S, Wan M, Wray J, Cooper M, Green J, Hudry K. Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism. JAMA Pediatrics 2021, 175: e213298. PMID: 34542577, PMCID: PMC8453361, DOI: 10.1001/jamapediatrics.2021.3298.Peer-Reviewed Original ResearchConceptsUsual careAge 3 yearsUsual care groupAutism spectrum disorderMeasures of child developmentCommunication Surveillance-RevisedPreemptive interventionSymptom severityCare groupIntervention groupCommunity cliniciansCaregiving responsibilitiesCommunication interventionsMain OutcomesAge 2 yearsAustralian research centerCareRandomized clinical trialsSecondary outcomesPrimary outcomeAssessment pointsAged 9No trialsAutism spectrum disorder symptom severityIntervention
2019
The minimal that kills: Why defining and targeting measurable residual disease is the “Sine Qua Non” for further progress in management of acute myeloid leukemia
Bewersdorf JP, Shallis RM, Boddu PC, Wood B, Radich J, Halene S, Zeidan AM. The minimal that kills: Why defining and targeting measurable residual disease is the “Sine Qua Non” for further progress in management of acute myeloid leukemia. Blood Reviews 2019, 43: 100650. PMID: 31883804, DOI: 10.1016/j.blre.2019.100650.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute myeloid leukemiaMyeloid leukemiaHard clinical outcomesClinical trial evidenceMeasurable residual diseaseResidual leukemic cellsRisk of relapseApprovable endpointsMRD statusDeep remissionMorphologic remissionMRD assessmentOverall survivalMRD levelsClinical outcomesDisease relapseInitial treatmentResidual diseaseTrial evidenceClinical trialsTreatment decisionsSurrogate endpointsBone marrowPreemptive interventionLeukemic cells
2018
Discharge Readiness after Robotic and Laparoscopic Hysterectomy
DeStephano C, Gajarawala S, Espinal M, Heckman M, Vargas E, Robertson M. Discharge Readiness after Robotic and Laparoscopic Hysterectomy. Journal Of Minimally Invasive Gynecology 2018, 26: 910-918. PMID: 30240901, DOI: 10.1016/j.jmig.2018.09.766.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCohort StudiesFemaleHumansHysterectomyLaparoscopyLength of StayMiddle AgedOperative TimePatient DischargePatient Outcome AssessmentPatient ReadmissionPatient SatisfactionPostoperative ComplicationsPostoperative PeriodRetrospective StudiesRobotic Surgical ProceduresTreatment OutcomeYoung AdultConceptsPostoperative phone callsLaparoscopic hysterectomyPostoperative symptomsPostoperative restrictionsNo significant predictorsSingle tertiary care centerOutcome measuresTertiary care centerGroup of patientsPrimary outcome measureAssociation of baselineUrogynecologic indicationsRobotic hysterectomyPostoperative characteristicsPostoperative complicationsPostoperative surveyHysterectomyOlder patientsPostoperative callsCancer indicationsSecondary outcomesPatientsRisk factorsCare centerPreemptive intervention
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