2021
Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics
Le TM, Potvin S, Zhornitsky S, Li CR. Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. Neuroscience & Biobehavioral Reviews 2021, 127: 255-269. PMID: 33933507, PMCID: PMC8411123, DOI: 10.1016/j.neubiorev.2021.04.028.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexMiddle frontal gyrusHealthy controlsLeft dorsal anterior cingulate cortexMFG activationSubstance use statusPrefrontal cortical dysfunctionAnterior cingulate cortexPrefrontal cortical regionsResponse inhibitionPopulation characteristicsImpaired task performanceInhibitory control deficitsCortical dysfunctionCerebral functionBenefits of abstinenceNicotine usersCortical activationCingulate cortexCortical regionsFrontal gyrusBrain activationDrug addictionUse statusControl deficits
2004
Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory
Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory. Science 2004, 306: 882-884. PMID: 15514161, DOI: 10.1126/science.1100021.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AgonistsAlkaloidsAnimalsBenzophenanthridinesCarbolinesElectrophysiologyEnzyme ActivationFemaleImidazolesLithium CarbonateMacaca mulattaMaleMemoryNeuronsPhenanthridinesPrefrontal CortexProtein Kinase CRatsRats, Sprague-DawleyReceptors, Adrenergic, alpha-1Signal TransductionStress, PhysiologicalTetradecanoylphorbol AcetateValproic AcidConceptsPrefrontal cortical regulationPrefrontal cortexPrefrontal cortical cognitive functionCortical regulationCortical cognitive functionsPrefrontal cortical dysfunctionWorking memoryElectrophysiological measuresCognitive functionRepresentational knowledgeThought disorderImpaired judgmentBrain regionsStress exposureMemoryCortical dysfunctionHigher brain regionsCortexThoughtDistractibilityEmotionsImpulsivityHigh levelsJudgmentsBehavior
1999
A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex
Birnbaum S, Gobeske K, Auerbach J, Taylor J, Arnsten A. A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex. Biological Psychiatry 1999, 46: 1266-1274. PMID: 10560032, DOI: 10.1016/s0006-3223(99)00138-9.Peer-Reviewed Original ResearchConceptsStress-induced cognitive deficitsPoor attention regulationAlternation performanceSpatial working memoryPFC cognitive functionPrefrontal cortical dysfunctionMotor response timeIntra-PFC infusionsStress-induced deficitsStress-induced impairmentWorking memoryAttention regulationPFC contributeMemory performanceAlternation testingStress researchNeuropsychiatric disordersPrefrontal cortexCognitive deficitsCognitive functionMemory functionMemory impairmentPFC dysfunctionPerseverative patternsPharmacological stressor
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