2017
B cells in the pathophysiology of myasthenia gravis
Yi JS, Guptill JT, Stathopoulos P, Nowak RJ, O’Connor K. B cells in the pathophysiology of myasthenia gravis. Muscle & Nerve 2017, 57: 172-184. PMID: 28940642, PMCID: PMC5767142, DOI: 10.1002/mus.25973.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMyasthenia gravisB cellsMuscle-specific tyrosine kinaseArchetypal autoimmune diseaseMuscle end platesProduction of autoantibodiesMost patientsPathogenic autoantibodiesAutoimmune diseasesAdaptive immunityHuman studiesAcetylcholine receptorsFunctional AChRsNeuromuscular junctionPostsynaptic proteinsAutoantibodiesCellular immunologyMolecular immunologyGravisImmunopathologyPathologyAChRImmunologyTyrosine kinaseEnd plates
2008
Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK
Kim N, Stiegler A, Cameron T, Hallock P, Gomez A, Huang J, Hubbard S, Dustin M, Burden S. Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK. Cell 2008, 135: 334-342. PMID: 18848351, PMCID: PMC2933840, DOI: 10.1016/j.cell.2008.10.002.Peer-Reviewed Original ResearchConceptsCongenital myasthenic syndromeSynaptic differentiationSpecialized release sitesAgrin activates MuSKNeuromuscular synapse formationReceptor tyrosine kinasesGroup of neuromuscular disordersLDLR familyMuSK activationDownstream effectorsSkeletal muscle fibersMuSK phosphorylationPostsynaptic proteinsPresynaptic nerve terminalsTyrosine kinaseMyasthenic syndromeSynapse formationMuscle membraneNerve terminalsAgrinMotor neuronsNeuromuscular synapsesRelease sitesActive zoneReceptors
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply