Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK
Kim N, Stiegler A, Cameron T, Hallock P, Gomez A, Huang J, Hubbard S, Dustin M, Burden S. Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK. Cell 2008, 135: 334-342. PMID: 18848351, PMCID: PMC2933840, DOI: 10.1016/j.cell.2008.10.002.Peer-Reviewed Original ResearchConceptsCongenital myasthenic syndromeSynaptic differentiationSpecialized release sitesAgrin activates MuSKNeuromuscular synapse formationReceptor tyrosine kinasesGroup of neuromuscular disordersLDLR familyMuSK activationDownstream effectorsSkeletal muscle fibersMuSK phosphorylationPostsynaptic proteinsPresynaptic nerve terminalsTyrosine kinaseMyasthenic syndromeSynapse formationMuscle membraneNerve terminalsAgrinMotor neuronsNeuromuscular synapsesRelease sitesActive zoneReceptors
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