2024
Covalent Polymer‐RNA Conjugates for Potent Activation of the RIG‐I Pathway
Palmer C, Pastora L, Kimmel B, Pagendarm H, Kwiatkowski A, Stone P, Arora K, Francini N, Fedorova O, Pyle A, Wilson J. Covalent Polymer‐RNA Conjugates for Potent Activation of the RIG‐I Pathway. Advanced Healthcare Materials 2024, 14: 2303815. PMID: 38648653, PMCID: PMC11493851, DOI: 10.1002/adhm.202303815.Peer-Reviewed Original ResearchChemical design principlesActivation of RIG-I.Retinoic acid-inducible gene ICovalent conjugationRIG-I pathwayNuclease degradationThioether linkageRIG-I.Gene IRNA ligandsElectrostatic interactionsRIG-IDevelopment of therapeuticsPotent activityOligonucleotide therapeuticsNucleaseRNAAnalog carrierNanoparticlesDrug delivery barriersConjugatePolymeric carriersImmunostimulatory activityThioethersIn vivo delivery
2017
Antimalarial Properties of Simplified Kalihinol Analogues
Daub ME, Prudhomme J, Mamoun C, Le Roch KG, Vanderwal CD. Antimalarial Properties of Simplified Kalihinol Analogues. ACS Medicinal Chemistry Letters 2017, 8: 355-360. PMID: 28337330, PMCID: PMC5346982, DOI: 10.1021/acsmedchemlett.7b00013.Peer-Reviewed Original ResearchNatural productsIsonitrile functional groupsPrevious total synthesisTotal synthesisFunctional groupsRepresentative compoundsReasonable stabilitySimple analogCompoundsAntimalarial propertiesAntimalarial activityAntimalarial agentsPotent activityAnaloguesInherent liabilitySclareolidePotent inhibitorSynthesisProductsScaffoldsKalihinolsStabilityAgentsProperties
2005
Potent 4-aminopiperidine based antimalarial agents
Brinner KM, Powles MA, Schmatz DM, Ellman JA. Potent 4-aminopiperidine based antimalarial agents. Bioorganic & Medicinal Chemistry Letters 2005, 15: 345-348. PMID: 15603951, DOI: 10.1016/j.bmcl.2004.10.069.Peer-Reviewed Original Research
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