2024
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
Kim B, Kim G, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Balachander S, Banaj N, Bargalló N, Batistuzzo M, Benedetti F, Bertolín S, Beucke J, Bollettini I, Brem S, Brennan B, Buitelaar J, Calvo R, Castelo-Branco M, Cheng Y, Chhatkuli R, Ciullo V, Coelho A, Couto B, Dallaspezia S, Ely B, Ferreira S, Fontaine M, Fouche J, Grazioplene R, Gruner P, Hagen K, Hansen B, Hanna G, Hirano Y, Höxter M, Hough M, Hu H, Huyser C, Ikuta T, Jahanshad N, James A, Jaspers-Fayer F, Kasprzak S, Kathmann N, Kaufmann C, Kim M, Koch K, Kvale G, Kwon J, Lazaro L, Lee J, Lochner C, Lu J, Manrique D, Martínez-Zalacaín I, Masuda Y, Matsumoto K, Maziero M, Menchón J, Minuzzi L, Moreira P, Morgado P, Narayanaswamy J, Narumoto J, Ortiz A, Ota J, Pariente J, Perriello C, Picó-Pérez M, Pittenger C, Poletti S, Real E, Reddy Y, van Rooij D, Sakai Y, Sato J, Segalas C, Shavitt R, Shen Z, Shimizu E, Shivakumar V, Soreni N, Soriano-Mas C, Sousa N, Sousa M, Spalletta G, Stern E, Stewart S, Szeszko P, Thomas R, Thomopoulos S, Vecchio D, Venkatasubramanian G, Vriend C, Walitza S, Wang Z, Watanabe A, Wolters L, Xu J, Yamada K, Yun J, Zarei M, Zhao Q, Zhu X, Thompson P, Bruin W, van Wingen G, Piras F, Piras F, Stein D, van den Heuvel O, Simpson H, Marsh R, Cha J. White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group. Molecular Psychiatry 2024, 29: 1063-1074. PMID: 38326559, PMCID: PMC11176060, DOI: 10.1038/s41380-023-02392-6.Peer-Reviewed Original ResearchObsessive-compulsive disorderNeurobiology of obsessive-compulsive disorderDiffusion tensor imagingENIGMA-OCD working groupClassification of obsessive-compulsive disorderGray matter morphometryWhite matter integrityCross-site generalizabilityHealthy controlsWhite matter pathwaysPosterior thalamic radiationWhite matter featuresMachine learning findingsLeave-one-site-out cross-validationOCD studiesThalamic radiationMedication effectsMultivariate patternsAdult participantsTensor imagingLearning interpretationNeurobiologyCorpus callosumLearning findingsInternal capsule
2022
The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial
Zarrabi M, Akbari M, Amanat M, Majmaa A, Moaiedi A, Montazerlotfelahi H, Nouri M, Hamidieh A, Badv R, Karimi H, Rabbani A, Mohebbi A, Rahimi-Dehgolan S, Rahimi R, Dehghan E, Vosough M, Abroun S, Shamsabadi F, Tavasoli A, Alizadeh H, Pak N, Zamani G, Mohammadi M, Javadzadeh M, Ghofrani M, Hassanpour S, Heidari M, Taghdiri M, Mohseni M, Noparast Z, Masoomi S, Goudarzi M, Mohamadpour M, Shodjaee R, Samimi S, Mohammad M, Gholami M, Vafaei N, Koochakzadeh L, Valizadeh A, Malamiri R, Ashrafi M. The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial. BMC Neurology 2022, 22: 123. PMID: 35351020, PMCID: PMC8966246, DOI: 10.1186/s12883-022-02636-y.Peer-Reviewed Original ResearchConceptsUmbilical cord blood mononuclear cellsCord blood mononuclear cellsSpastic cerebral palsyBlood mononuclear cellsCerebral palsyHuman leukocyte antigenPosterior thalamic radiationUCB-MNCAdverse eventsFractional anisotropyMononuclear cellsCorticospinal tractWhite matter structuresMean changeDouble-blind sham-controlled clinical trialControl groupMean GMFM-66 scoresGross Motor Function MeasureSham-controlled clinical trialExperimental groupCommon adverse eventsDouble-blind studyMotor Function MeasureGMFM-66 scoresTrial registrationThe study
2021
Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial
Amanat M, Majmaa A, Zarrabi M, Nouri M, Akbari MG, Moaiedi AR, Ghaemi O, Zamani F, Najafi S, Badv RS, Vosough M, Hamidieh AA, Salehi M, Montazerlotfelahi H, Tavasoli AR, Heidari M, Mohebi H, Fatemi A, Garakani A, Ashrafi MR. Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial. Stem Cell Research & Therapy 2021, 12: 439. PMID: 34362453, PMCID: PMC8343813, DOI: 10.1186/s13287-021-02513-4.Peer-Reviewed Original ResearchConceptsModified Ashworth ScaleCerebral palsyMean changeTissue mesenchymal stem cellsPosterior thalamic radiationDiffusion tensor imagingIntrathecal injectionFractional anisotropyCorticospinal tractDouble-blind sham-controlled clinical trialControl groupMesenchymal stem cellsMean GMFM-66 scoresGross Motor Function MeasureSham-controlled clinical trialSham control armSpastic cerebral palsyMotor Function MeasureGMFM-66 scoresTrial registrationThe studyMonths of interventionExperimental groupWhite matter integrityStem cellsCP-QOL
2020
Altered striatum centered brain structures in SHANK3 deficient Chinese children with genotype and phenotype profiling
Liu C, Li D, Yang H, Li H, Xu Q, Zhou B, Hu C, Li C, Wang Y, Qiao Z, Jiang YH, Xu X. Altered striatum centered brain structures in SHANK3 deficient Chinese children with genotype and phenotype profiling. Progress In Neurobiology 2020, 200: 101985. PMID: 33388374, PMCID: PMC8572121, DOI: 10.1016/j.pneurobio.2020.101985.Peer-Reviewed Original ResearchConceptsTract-based spatial statisticsVoxel-based morphometryUnderlying neuropathological mechanismsNeuropathological mechanismsDeficient childrenBrain structuresMiddle cerebral peduncleAutism spectrum disorderAbnormal neural circuitsPosterior thalamic radiationGray matter volumeFunctional connectivity studiesSuperior longitudinal fasciculusStudy of subjectsCerebral peduncleInternal capsuleRisk factorsDental abnormalitiesCorpus callosumCommissural fibersHematological problemsCorona radiataDorsal striatumNeurobehavioral evaluationAnteverted nares
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