2015
Alternative Polyadenylation Allows Differential Negative Feedback of Human miRNA miR-579 on Its Host Gene ZFR
Hinske L, Galante P, Limbeck E, Möhnle P, Parmigiani R, Ohno-Machado L, Camargo A, Kreth S. Alternative Polyadenylation Allows Differential Negative Feedback of Human miRNA miR-579 on Its Host Gene ZFR. PLOS ONE 2015, 10: e0121507. PMID: 25799583, PMCID: PMC4370670, DOI: 10.1371/journal.pone.0121507.Peer-Reviewed Original ResearchConceptsHost genesAlternative polyadenylationIntronic miRNAsMiR-579Protein-coding host genesPotential miRNA binding sitesHost gene expressionMiRNA binding sitesIntronic miRNAMiRNA genesNegative feedback loopRNA-seqPolyadenylation signalPolyadenylation sitesBioinformatics analysisCell line modelsGene expressionSilico analysisDifferential targetingPolyadenylationGenesMiRNAsZFRBinding sitesNegative feedback
2010
The Landscape of C. elegans 3′UTRs
Mangone M, Manoharan A, Thierry-Mieg D, Thierry-Mieg J, Han T, Mackowiak S, Mis E, Zegar C, Gutwein M, Khivansara V, Attie O, Chen K, Salehi-Ashtiani K, Vidal M, Harkins T, Bouffard P, Suzuki Y, Sugano S, Kohara Y, Rajewsky N, Piano F, Gunsalus K, Kim J. The Landscape of C. elegans 3′UTRs. Science 2010, 329: 432-435. PMID: 20522740, PMCID: PMC3142571, DOI: 10.1126/science.1191244.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAnimalsBinding SitesCaenorhabditis elegansComputational BiologyConserved SequenceDisorders of Sex DevelopmentGene Expression Regulation, DevelopmentalGene LibraryGenes, HelminthHelminth ProteinsHistonesMaleMicroRNAsOperonPoly APolyadenylationRNA, HelminthRNA, MessengerTrans-SplicingConceptsMetazoan messenger RNAsPolyadenylation signalComplementary DNAProtein-coding genesAmplification of complementary DNAMicroRNA target sitesVariant polyadenylation signalHistone genesGenome-widePolyadenylation sitesAlternative isoformsTrans-splicingGene modelsRNA-seqRegulatory elementsCaenorhabditis elegansLong 3'UTRUntranslated regionIsoform specificityPolyadenylationGenesMessenger RNATarget siteIsoformsAnimal age
2003
Characterization of the CYP4A11 gene, a second CYP4A gene in humans
Bellamine A, Wang Y, Waterman MR, Gainer JV, Dawson EP, Brown NJ, Capdevila JH. Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Archives Of Biochemistry And Biophysics 2003, 409: 221-227. PMID: 12464262, DOI: 10.1016/s0003-9861(02)00545-3.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, SouthernCloning, MolecularCytochrome P-450 CYP4ACytochrome P-450 Enzyme SystemExonsGene DeletionHumansHydroxyeicosatetraenoic AcidsIntronsKidneyMixed Function OxygenasesModels, GeneticMolecular Sequence DataPolymerase Chain ReactionProtein IsoformsReverse Transcriptase Polymerase Chain ReactionRNA
1997
Structure and Organization of the Human Ankyrin-1 Gene BASIS FOR COMPLEXITY OF PRE-mRNA PROCESSING*
Gallagher P, Tse W, Scarpa A, Lux S, Forget B. Structure and Organization of the Human Ankyrin-1 Gene BASIS FOR COMPLEXITY OF PRE-mRNA PROCESSING*. Journal Of Biological Chemistry 1997, 272: 19220-19228. PMID: 9235914, DOI: 10.1074/jbc.272.31.19220.Peer-Reviewed Original ResearchConceptsGenomic structureANK-1 geneSpectrin-binding domainMembrane-binding domainIntron/exon boundariesAlternative polyadenylation signalsPre-mRNA processingBrain-specific transcriptFurther genetic studiesErythrocyte membrane proteinsErythroid transcriptsCommon hemolytic anemiaGene basisAlternative splicingRegulatory domainProtein domainsChromosomal genesMembrane proteinsKilobase pairsPolyadenylation signalMembrane skeletonPlasma membraneExon boundariesGenetic studiesAnkyrin 1
1996
The minimal conserved transcription stop-start signal promotes stable expression of a foreign gene in vesicular stomatitis virus
Schnell M, Buonocore L, Whitt M, Rose J. The minimal conserved transcription stop-start signal promotes stable expression of a foreign gene in vesicular stomatitis virus. Journal Of Virology 1996, 70: 2318-2323. PMID: 8642658, PMCID: PMC190073, DOI: 10.1128/jvi.70.4.2318-2323.1996.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceChloramphenicol O-AcetyltransferaseCloning, MolecularConserved SequenceGene Expression Regulation, ViralMembrane GlycoproteinsMolecular Sequence DataRegulatory Sequences, Nucleic AcidRNA, ViralSerial PassageTranscription, GeneticVesicular stomatitis Indiana virusViral Envelope ProteinsViral Plaque AssayConceptsForeign genesBacterial enzyme chloramphenicolNew transcription unitTranscription start sequenceWild-type titersTranscription unitFunctional chloramphenicolPolyadenylation signalEnzyme chloramphenicolCell biologyVesicular stomatitis virusVSV genomeIntergenic dinucleotideGene junctionStable expressionGlycoprotein geneGenesDNA copiesGlycoprotein mRNAInfectious VSVRecombinant virusesStomatitis virusStart sequenceRecombinant VSVSequence
1995
Structure, Organization, and Expression of the Human Band 7.2b Gene, a Candidate Gene for Hereditary Hydrocytosis (∗)
Gallagher P, Forget B. Structure, Organization, and Expression of the Human Band 7.2b Gene, a Candidate Gene for Hereditary Hydrocytosis (∗). Journal Of Biological Chemistry 1995, 270: 26358-26363. PMID: 7592848, DOI: 10.1074/jbc.270.44.26358.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAmino Acid SequenceAnemia, HemolyticAnimalsBase SequenceBlood ProteinsBlotting, NorthernCell LineConsensus SequenceDNA PrimersDNA, ComplementaryExonsGene ExpressionGenetic VariationHominidaeHumansIntronsLeukemia, Erythroblastic, AcuteMembrane ProteinsMiceMolecular Sequence DataPolymerase Chain ReactionPolymorphism, GeneticPromoter Regions, GeneticRecombinant Fusion ProteinsRegulatory Sequences, Nucleic AcidRestriction MappingRNA, MessengerTransfectionTumor Cells, CulturedConceptsSingle transcription initiation siteSimple sequence repeat polymorphismKilobases of DNATranscription initiation siteAlternative polyadenylation signalsFurther genetic studiesHigh-level expressionNorthern blot analysisPattern of expressionWide tissue distributionGenomic structureRich promoterNonerythroid cellsChromosomal genesPolyadenylation signalMembrane skeletonGene cDNAGene promoterReporter geneCandidate genesRecognition sequenceGenetic studiesInitiation siteGenesBase pairs
1991
[4] Assays for Biosynthesis of Thyrotropin-Releasing Hormone
Nillni E, Sevarino K, Wu P, Jackson I. [4] Assays for Biosynthesis of Thyrotropin-Releasing Hormone. International Review Of Neurobiology 1991, 6: 51-69. DOI: 10.1016/b978-0-12-185261-0.50009-5.Peer-Reviewed Original ResearchStandard molecular biological techniquesTranscriptional termination signalCloning siteMammalian cell linesMoloney mouse leukemia virusMolecular biological techniquesT-antigen geneRous sarcoma virusMammalian cellsTermination signalBamH1 fragmentPolyadenylation signalEcoR1 fragmentUnique cloning sitesPrecursor sequencesCytomegalovirus immediate early promoterImmediate early promoterMouse leukemia virusViral promotersExpression vectorSmall-T-antigen genePromoterSarcoma virusBiological techniquesAntigen gene
1988
Four novel U RNAs are encoded by a herpesvirus
Lee S, Murthy S, Trimble J, Desrosiers R, Steitz J. Four novel U RNAs are encoded by a herpesvirus. Cell 1988, 54: 599-607. PMID: 2842058, DOI: 10.1016/s0092-8674(88)80004-7.Peer-Reviewed Original ResearchConceptsHSUR 1U RNAU RNA genesTrimethylguanosine cap structureSmall nuclear ribonucleoproteinEnd formation signalsAAUAAA polyadenylation signalBase pairing interactionsRNA genesMarmoset T lymphocytesPolyadenylation signalNuclear ribonucleoproteinCap structureEnd sequencesPerfect complementarityViral genesSnRNP particlesLow abundanceHerpesvirus saimiriRNASm determinantsGenesFormation signalEnd regionSequence
1985
Conservation and variability of wheat α/β-gliadin genes
Sumner-Smith M, Rafalski J, Sugiyama T, Stoll M, Sōll D. Conservation and variability of wheat α/β-gliadin genes. Nucleic Acids Research 1985, 13: 3905-3916. PMID: 3839304, PMCID: PMC341285, DOI: 10.1093/nar/13.11.3905.Peer-Reviewed Original ResearchConceptsTypical eukaryotic promoterStorage protein genesEvolutionary relatednessGenomic clonesGliadin genesEukaryotic promotersGliadin familyProtein genePolyadenylation signalPolyglutamine stretchGene multiplicationClose homologyGlutamine codonGenesCertain mutationsCodonUnusual structureP-boxesIntronsHomologyPromoterPlantsProlineClonesRelatedness
1980
Complete intergenic and flanking gene sequences from the genome of vesicular stomatitis virus
Rose J. Complete intergenic and flanking gene sequences from the genome of vesicular stomatitis virus. Cell 1980, 19: 415-421. PMID: 6244108, DOI: 10.1016/0092-8674(80)90515-2.Peer-Reviewed Original ResearchConceptsGene sequencesPossible promoter sequenceFrame AUG codonsIntergenic regionTranscription eventsVSV transcriptionPromoter sequencesExtensive homologyMRNA structurePolyadenylation signalNucleotide sequenceAUG codonVesicular stomatitis virusL geneRNA regionsMRNA sequencesVSV genesTerminal sequenceVSV mRNAsN mRNAStomatitis virusG mRNAMRNARibosomesVariable positions
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply