2015
Antidepressants for neuroprotection in Huntington's disease: A review
Jamwal S, Kumar P. Antidepressants for neuroprotection in Huntington's disease: A review. European Journal Of Pharmacology 2015, 769: 33-42. PMID: 26511378, DOI: 10.1016/j.ejphar.2015.10.033.Peer-Reviewed Original ResearchConceptsHuntingtin proteinHuntington's diseaseMAPK/ERK signalingBrain-derived neurotrophic factor (BDNF) productionBDNF/TrkB pathwayProgression of HDDifferent neuroprotective mechanismsPrincipal neuropathological hallmarksUse of antidepressantsNeurotrophic factor productionCortical projection neuronsMutant huntingtin proteinCellular functionsPolyglutamine stretchMolecular mechanismsNH2 terminusERK signalingTrkB pathwayPreclinical evidenceNeuroprotective effectsNeuroprotective mechanismsCommon symptomsProjection neuronsAvailable treatmentsDisease progression
1985
Conservation and variability of wheat α/β-gliadin genes
Sumner-Smith M, Rafalski J, Sugiyama T, Stoll M, Sōll D. Conservation and variability of wheat α/β-gliadin genes. Nucleic Acids Research 1985, 13: 3905-3916. PMID: 3839304, PMCID: PMC341285, DOI: 10.1093/nar/13.11.3905.Peer-Reviewed Original ResearchConceptsTypical eukaryotic promoterStorage protein genesEvolutionary relatednessGenomic clonesGliadin genesEukaryotic promotersGliadin familyProtein genePolyadenylation signalPolyglutamine stretchGene multiplicationClose homologyGlutamine codonGenesCertain mutationsCodonUnusual structureP-boxesIntronsHomologyPromoterPlantsProlineClonesRelatedness
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