2025
PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma
Guo M, Chen S, Sun J, Xu R, Qi Z, Li J, Zhou L, Fang Y, Liu T, Xia J. PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma. Advanced Science 2025, e04372. PMID: 40405713, DOI: 10.1002/advs.202504372.Peer-Reviewed Original ResearchNrf2-dependent transcriptionHepatocellular carcinomaKinase-independent mannerProgrammed Cell DeathKelch domain of Kelch-like ECH-associated protein 1Sensitizes HCC cells to sorafenibHepatocellular carcinoma tumorigenesisIron-dependent formInduced sorafenib resistanceKelch domainPIP5K1AKelch-like ECH-associated protein 1Inhibit HCC growthCells to sorafenibECH-associated protein 1Cell deathSorafenib-induced ferroptosisEfficacy of sorafenibHepatocellular carcinoma patientsFerroptosis resistanceCancer-related mortalityUbiquitination degradationFerroptosis inducersProtein 1Stabilize Nrf2
2015
Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled
Hu J, Yuan Q, Kang X, Qin Y, Li L, Ha Y, Wu D. Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled. Nature Communications 2015, 6: 8205. PMID: 26365782, PMCID: PMC4570271, DOI: 10.1038/ncomms9205.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsBinding SitesCalorimetryCatalytic DomainCircular DichroismCrystallizationCrystallography, X-RayDimerizationDishevelled ProteinsHEK293 CellsHumansPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol PhosphatesPhosphoproteinsPhosphorylationPhosphotransferases (Alcohol Group Acceptor)Protein Structure, TertiaryZebrafishConceptsSubstrate-binding siteLipid kinasesDIX domainCellular functionsCatalytic domainPhosphate kinaseÅ resolutionMutagenesis studiesRegulatory mechanismsMolecular mechanismsCatalytic activityPIP5K1AHead groupsCrystal structureSide dimerKinaseWntStructural informationRegulationDimerizationMoleculesResolution of structuresImportant rolePhosphatidylinositolType I
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