2023
222-OR: Metformin Reduces Fasting Glycemia in Well-Controlled Type 2 Diabetes by Promoting Aerobic Glycolysis Independent of Decreasing Endogenous Glucose Production
SARABHAI T, LAMOIA T, FRIESL S, JONUSCHEIT M, PETERSEN K, SHULMAN G, RODEN M. 222-OR: Metformin Reduces Fasting Glycemia in Well-Controlled Type 2 Diabetes by Promoting Aerobic Glycolysis Independent of Decreasing Endogenous Glucose Production. Diabetes 2023, 72 DOI: 10.2337/db23-222-or.Peer-Reviewed Original ResearchEndogenous glucose productionRates of EGPType 2 diabetesHepatic ATP contentMetformin treatmentGlucose clearanceNovo NordiskGlucose productionGlycogen contentGlucose-lowering effectHepatic TAG contentLactate productionBlood glucose levelsPlasma glucose concentrationPeripheral glucose clearanceHepatic glycogen contentATP contentAdvisory PanelFortress BiotechMetformin-induced inhibitionGlycemic controlDohme Corp.Hepatic triglyceridesMitochondrial electron transport chain activityGlucose levels
2013
Efficient utilization of aerobic metabolism helps Tibetan locusts conquer hypoxia
Zhao D, Zhang Z, Cease A, Harrison J, Kang L. Efficient utilization of aerobic metabolism helps Tibetan locusts conquer hypoxia. BMC Genomics 2013, 14: 631. PMID: 24047108, PMCID: PMC3852963, DOI: 10.1186/1471-2164-14-631.Peer-Reviewed Original ResearchConceptsAerobic metabolismBasic metabolic processesExtreme hypoxiaTranscriptional responseHigh-altitude Tibetan PlateauGeographical populationsTCA cycleMigratory locustHypoxia toleranceMetabolic processesLocusta migratoriaHypoxic responseEntry genesLocustPhysiological perspectiveATP contentMetabolismTibetan PlateauInvertebratesInsectsDifferent altitudesGenesSpeciesHypoxiaConclusionsOur results
1996
The antibacterial action of protamine: evidence for disruption of cytoplasmic membrane energization in Salmonella typhimurium
Aspedon A, Groisman EA. The antibacterial action of protamine: evidence for disruption of cytoplasmic membrane energization in Salmonella typhimurium. Microbiology 1996, 142: 3389-3397. PMID: 9004502, DOI: 10.1099/13500872-142-12-3389.Peer-Reviewed Original ResearchConceptsCytoplasmic membraneNuclei of spermNutrient uptake functionsCellular ATP contentElectrical membrane potentialHigher delta psi valuesRespiring cellsLoss of viabilityMembrane energizationDifferent animal speciesProline uptakeProtein synthesisEnergy transductionMode of actionAnimal speciesUptake functionDelta psi valuesMembrane potentialCell lysisRapid effluxMechanism of actionPolycationic peptidesATP contentProtamineSalmonella typhimurium
1995
ATP depletion and inactivation of an ATP-sensitive taurine channel by classic ion channel blockers.
Ballatori N, Truong A, Jackson P, Strange K, Boyer J. ATP depletion and inactivation of an ATP-sensitive taurine channel by classic ion channel blockers. Molecular Pharmacology 1995, 48: 472-476. PMID: 7565627, DOI: 10.1016/s0026-895x(25)10495-1.Peer-Reviewed Original ResearchConceptsIon channel blockersChannel blockersVolume-activated anion channelsATP levelsATP contentActivity of ATPPhysiologic alterationsIntracellular ATP levelsCellular ATPTaurine effluxBlockersIntracellular ATP contentTaurine channelCellular ATP levelsATP/ADP ratioIntracellular organic osmolytesSkate hepatocytesIntracellular ATPATP depletionCell volume regulationDifferent cell typesEffluxCellular ATP concentrationMetabolic poisonsCell types
1989
Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase
Van Waarde A, Stromski M, Thulin G, Gaudio K, Kashgarian M, Shulman R, Siegel N. Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase. American Journal Of Physiology 1989, 256: f298-f305. PMID: 2537026, DOI: 10.1152/ajprenal.1989.256.2.f298.Peer-Reviewed Original ResearchConceptsRenal ischemic insultResidual nucleotide poolMin of ischemiaRenal ATP contentFunctional recoveryIschemic injuryIschemic insultKidney functionRenal ischemiaIntramuscular injectionUntreated ratsRapid initial recoveryATP restorationRat kidneyRenal ATPIschemiaInitial recoveryKidneyRatsATP contentInsultFunctional consequencesNucleotide poolMagnetic resonanceAMPCP
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