2025
International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation
Sahin O, Kamel S, Wahid K, Dede C, Taku N, He R, Naser M, Sharafi C, Mäkitie A, Kann B, Kaski K, Sahlsten J, Jaskari J, Amit M, Chronowski G, Diaz E, Garden A, Goepfert R, Guenette J, Gunn G, Hirvonen J, Hoebers F, Hutcheson K, Guha‐Thakurta N, Johnson J, Kaya D, Khanpara S, Nyman K, Lai S, Lango M, Learned K, Lee A, Lewis C, Maniakas A, Moreno A, Myers J, Phan J, Pytynia K, Rosenthal D, Sandulache V, Schellingerhout D, Shah S, Sikora A, Mohamed A, Chen M, Fuller C, Group M. International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation. Cancer 2025, 131: e35815. PMID: 40159431, PMCID: PMC12067423, DOI: 10.1002/cncr.35815.Peer-Reviewed Original ResearchConceptsPathologic extranodal extensionOropharyngeal cancerExtranodal extensionComputed tomographyClinician specialtyHPV-positive OPC patientsHuman papillomavirus (HPV)-positive oropharyngeal cancerHPV-positive oropharyngeal cancerReceiver operating characteristic curveArea under the receiver operating characteristic curveInter-observer variabilityOPC patientsNodal necrosisPrognostic factorsRadiological criteriaInterobserver agreementDiagnostic performanceBrier scoreCT imagesFleiss' kappaCharacteristic curvePredictive signLogistic regressionPatientsCancer
2020
Prognostic Significance of Extranodal Extension in HPV‐Mediated Oropharyngeal Carcinoma: A Systematic Review and Meta‐analysis
Benchetrit L, Torabi SJ, Givi B, Haughey B, Judson BL. Prognostic Significance of Extranodal Extension in HPV‐Mediated Oropharyngeal Carcinoma: A Systematic Review and Meta‐analysis. Otolaryngology 2020, 164: 720-732. PMID: 32838649, DOI: 10.1177/0194599820951176.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaExtranodal extensionHazard ratioSystematic reviewHuman papilloma virus-positive oropharyngeal squamous cell carcinomaPathologic extranodal extensionDisease-specific survivalCohort of patientsRefined risk stratificationSquamous cell carcinomaRadiologic extranodal extensionRandom-effects modelDeintensification trialsCause mortalityDistant recurrenceLocoregional recurrenceOverall survivalOropharyngeal carcinomaPrognostic roleDistant metastasisRisk stratificationPrognostic significanceCell carcinomaPrognostic outcomesObservational study
2019
1149P Pathologic staging changes in oral cavity squamous cell carcinoma: Stage migration and implications for adjuvant treatment
Husain Z, Lee N, Eskander A, Park H, mehra S, Burtness B. 1149P Pathologic staging changes in oral cavity squamous cell carcinoma: Stage migration and implications for adjuvant treatment. Annals Of Oncology 2019, 30: v466. DOI: 10.1093/annonc/mdz252.041.Peer-Reviewed Original ResearchOral cavity squamous cell carcinomaPathologic extranodal extensionDepth of invasionSquamous cell carcinomaPT3N0 patientsOverall survivalStage migrationCell carcinomaStaging systemAJCC-8 staging systemFive-year overall survivalNational InstitutePathologic tumor classificationNational Cancer DatabaseAmerican Joint CommitteeRisk of deathNew staging systemBristol-Myers SquibbPStage IVBUpstaged tumorsDefinitive surgeryPostoperative radiotherapyPT3 tumorsAdjuvant treatmentExtranodal extensionPathologic staging changes in oral cavity squamous cell carcinoma: Stage migration and implications for adjuvant treatment
Lee NCJ, Eskander A, Park HS, Mehra S, Burtness BA, Husain Z. Pathologic staging changes in oral cavity squamous cell carcinoma: Stage migration and implications for adjuvant treatment. Cancer 2019, 125: 2975-2983. PMID: 31090934, DOI: 10.1002/cncr.32161.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell carcinomaPathologic extranodal extensionDepth of invasionAJCC Cancer Staging ManualCancer Staging ManualSquamous cell carcinomaOverall survivalPT3N0 patientsStage migrationStaging ManualCell carcinomaStaging systemAJCC-8 staging systemPathologic tumor classificationNational Cancer DatabaseRisk of deathNew staging systemPStage IVBUpstaged tumorsAdjuvant treatmentDefinitive surgeryExtranodal extensionPostoperative radiotherapyPT classificationPT1 tumors
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