International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation
Sahin O, Kamel S, Wahid K, Dede C, Taku N, He R, Naser M, Sharafi C, Mäkitie A, Kann B, Kaski K, Sahlsten J, Jaskari J, Amit M, Chronowski G, Diaz E, Garden A, Goepfert R, Guenette J, Gunn G, Hirvonen J, Hoebers F, Hutcheson K, Guha‐Thakurta N, Johnson J, Kaya D, Khanpara S, Nyman K, Lai S, Lango M, Learned K, Lee A, Lewis C, Maniakas A, Moreno A, Myers J, Phan J, Pytynia K, Rosenthal D, Sandulache V, Schellingerhout D, Shah S, Sikora A, Mohamed A, Chen M, Fuller C, Group M. International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation. Cancer 2025, 131: e35815. PMID: 40159431, PMCID: PMC12067423, DOI: 10.1002/cncr.35815.Peer-Reviewed Original ResearchConceptsPathologic extranodal extensionOropharyngeal cancerExtranodal extensionComputed tomographyClinician specialtyHPV-positive OPC patientsHuman papillomavirus (HPV)-positive oropharyngeal cancerHPV-positive oropharyngeal cancerReceiver operating characteristic curveArea under the receiver operating characteristic curveInter-observer variabilityOPC patientsNodal necrosisPrognostic factorsRadiological criteriaInterobserver agreementDiagnostic performanceBrier scoreCT imagesFleiss' kappaCharacteristic curvePredictive signLogistic regressionPatientsCancer
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