2024
Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts
Kals M, Wilson L, Levey D, Parodi L, Steyerberg E, Richardson S, He F, Sun X, Jain S, Palotie A, Ripatti S, Rosand J, Manley G, Maas A, Stein M, Menon D, Consortium T, Ackerlund C, Adams H, Amrein K, Andelic N, Andreassen L, Anke A, Antoni A, Audibert G, Azouvi P, Azzolini M, Bartels R, Barzó P, Beauvais R, Beer R, Bellander B, Belli A, Benali H, Berardino M, Beretta L, Blaabjerg M, Bragge P, Brazinova A, Brinck V, Brooker J, Brorsson C, Buki A, Bullinger M, Cabeleira M, Caccioppola A, Calappi E, Calvi M, Cameron P, Lozano G, Carbonara M, Castaño-León A, Cavallo S, Chevallard G, Chieregato A, Citerio G, Clusmann H, Coburn M, Coles J, Cooper J, Correia M, Čović A, Curry N, Czeiter E, Czosnyka M, Dahyot-Fizelier C, Dark P, Dawes H, De Keyser V, Degos V, Della Corte F, Boogert H, Depreitere B, Đilvesi Đ, Dixit A, Donoghue E, Dreier J, Dulière G, Ercole A, Esser P, Ezer E, Fabricius M, Feigin V, Foks K, Frisvold S, Furmanov A, Gagliardo P, Galanaud D, Gantner D, Gao G, George P, Ghuysen A, Giga L, Glocker B, Golubović J, Gomez P, Gratz J, Gravesteijn B, Grossi F, Gruen R, Gupta D, Haagsma J, Haitsma I, Helbok R, Helseth E, Horton L, Huijben J, Hutchinson P, Jacobs B, Jankowski S, Jarrett M, Jiang J, Johnson F, Jones K, Karan M, Kolias A, Kompanje E, Kondziella D, Koskinen L, Kovács N, Kowark A, Lagares A, Lanyon L, Laureys S, Lecky F, Ledoux D, Lefering R, Legrand V, Lejeune A, Levi L, Lightfoot R, Lingsma H, Maegele M, Majdan M, Manara A, Maréchal H, Martino C, Mattern J, McFadyen C, McMahon C, Melegh B, Menovsky T, Mikolic A, Misset B, Muraleedharan V, Murray L, Negru A, Nelson D, Newcombe V, Nieboer D, Nyirádi J, Oresic M, Ortolano F, Otesile O, Parizel P, Payen J, Perera N, Perlbarg V, Persona P, Peul W, Piippo-Karjalainen A, Pirinen M, Pisica D, Ples H, Polinder S, Pomposo I, Posti J, Puybasset L, Rădoi A, Ragauskas A, Raj R, Rambadagalla M, Rehorčíková V, Helmrich I, Rhodes J, Richter S, Rocka S, Roe C, Roise O, Rosenfeld J, Rosenlund C, Rosenthal G, Rossaint R, Rossi S, Rueckert D, Rusnák M, Sahuquillo J, Sakowitz O, Sanchez-Porras R, Sandor J, Schäfer N, Schmidt S, Schoechl H, Schoonman G, Schou R, Schwendenwein E, Sewalt C, Singh R, Skandsen T, Smielewski P, Sorinola A, Stamatakis E, Stanworth S, Stevens R, Stewart W, Stocchetti N, Sundström N, Takala R, Tamás V, Tamosuitis T, Taylor M, Ao B, Tenovuo O, Theadom A, Thibaut A, Thomas M, Tibboel D, Timmers M, Tolias C, Trapani T, Tudora C, Unterberg A, Vajkoczy P, Valeinis E, Vallance S, Vámos Z, van der Jagt M, van der Naalt J, Van der Steen G, van Dijck J, van Erp I, van Essen T, Van Hecke W, van Heugten C, Van Praag D, van Veen E, van Wijk R, Vyvere T, Vargiolu A, Vega E, Velt K, Verheyden J, Vespa P, Vik A, Vilcinis R, Volovici V, von Steinbüchel N, Voormolen D, Vulekovic P, Whitehouse D, Wiegers E, Williams G, Wolf S, Yang Z, Ylén P, Younsi A, Zeiler F, Ziverte A, Zoerle T, Adeoye O, Badjatia N, Barber J, Bergin M, Boase K, Bodien Y, Chesnut R, Corrigan J, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime A, Ellenbogen R, Feeser V, Ferguson A, Foreman B, Gaudette E, Giacino J, Gonzalez L, Gopinath S, Grandhi R, Gullapalli R, Hemphill C, Hotz G, Huie R, Jha R, Keene D, Kitagawa R, Korley F, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, McCrea M, Merchant R, Mukherjee P, Nelson L, Ngwenya L, Noel F, Nolan A, Okonkwo D, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson C, Rodgers R, Rosenthal E, Sander A, Sandsmark D, Schneider A, Schnyer D, Seabury S, Sherer M, Sugar G, Temkin N, Toga A, Torres-Espin A, Valadka A, Vassar M, Wang K, Wang V, Yue J, Yuh E, Zafonte R. Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts. EClinicalMedicine 2024, 78: 102956. PMID: 39720422, PMCID: PMC11667043, DOI: 10.1016/j.eclinm.2024.102956.Peer-Reviewed Original ResearchPost-traumatic stress disorderMild traumatic brain injuryPolygenic risk scoresPTSD-PRSMDD-PRSTraumatic brain injuryTRACK-TBIProportion of outcome variancePost-traumatic Stress Disorder Checklist-5Odds of post-traumatic stress disorderAdverse mental health outcomesAssociations of polygenic risk scoresBrain injuryPatient Health Questionnaire-9Mental health outcomesOdds ratioMonths post-injuryRisk of depressionDisorder-specificDepressive disorderStress disorderChecklist-5Genetic vulnerabilityOutcome varianceCohort of African Americans
2022
Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes
Manzali S, Yu E, Ravona-Springer R, Livny A, Golan S, Ouyang Y, Lesman-Segev O, Liu L, Ganmore I, Alkelai A, Gan-Or Z, Lin H, Heymann A, Beeri M, Greenbaum L. Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes. Frontiers In Aging Neuroscience 2022, 14: 853695. PMID: 36110429, PMCID: PMC9468264, DOI: 10.3389/fnagi.2022.853695.Peer-Reviewed Original ResearchAssociations of polygenic risk scoresPolygenic risk scoresLate-onset Alzheimer's diseaseOlder adultsAlzheimer’s disease polygenic risk scoreCognitive declineType 2 diabetesGlobal cognitionAssociated with overall functioningRisk scoreRate of cognitive declineDomains of episodic memoryAssociated with cognitive declineVolumes of total gray matterMultiple risk lociSpecific cognitive domainsLanguage/semantic categorizationOverall cognitive functionAlzheimer's diseaseTotal gray matterIsrael DiabetesBrain imaging phenotypesOutcome measuresSusceptibility lociAttention/working memory
2018
Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative
Fritsche L, Gruber S, Wu Z, Schmidt E, Zawistowski M, Moser S, Blanc V, Brummett C, Kheterpal S, Abecasis G, Mukherjee B. Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative. American Journal Of Human Genetics 2018, 102: 1048-1061. PMID: 29779563, PMCID: PMC5992124, DOI: 10.1016/j.ajhg.2018.04.001.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresElectronic health recordsAssociations of polygenic risk scoresPhenome-wide significant associationsPolygenic risk score associationsLongitudinal biorepository effortNon-cancer diagnosesPatients' electronic health recordsPhenome-wide association studyAnalysis of temporal orderMichigan Genomics InitiativeRisk scoreAssociated with multiple phenotypesFemale breast cancerNHGRI-EBI CatalogRisk profileGenetic risk profilesMeasures of genomic variationCancer traitsCase-control studyPheWAS analysisHealth recordsHealth systemMichigan MedicineCancer diagnosis
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