2022
Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes
Manzali S, Yu E, Ravona-Springer R, Livny A, Golan S, Ouyang Y, Lesman-Segev O, Liu L, Ganmore I, Alkelai A, Gan-Or Z, Lin H, Heymann A, Beeri M, Greenbaum L. Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes. Frontiers In Aging Neuroscience 2022, 14: 853695. PMID: 36110429, PMCID: PMC9468264, DOI: 10.3389/fnagi.2022.853695.Peer-Reviewed Original ResearchAssociations of polygenic risk scoresPolygenic risk scoresLate-onset Alzheimer's diseaseOlder adultsAlzheimer’s disease polygenic risk scoreCognitive declineType 2 diabetesGlobal cognitionAssociated with overall functioningRisk scoreRate of cognitive declineDomains of episodic memoryAssociated with cognitive declineVolumes of total gray matterMultiple risk lociSpecific cognitive domainsLanguage/semantic categorizationOverall cognitive functionAlzheimer's diseaseTotal gray matterIsrael DiabetesBrain imaging phenotypesOutcome measuresSusceptibility lociAttention/working memory
2021
No evidence for association of Alzheimer’s disease risk loci with the rate of cognitive decline among elderly with type 2 diabetes
Greenbaum L, Manzali S, Ravona‐Springer R, Lin H, Beeri M. No evidence for association of Alzheimer’s disease risk loci with the rate of cognitive decline among elderly with type 2 diabetes. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.050081.Peer-Reviewed Original ResearchPolygenic risk scoresLate-onset Alzheimer's diseaseRate of cognitive declineDisease risk lociCognitive declineType 2 diabetesPopulation of older adultsAssociated with specific cognitive domainsRisk of dementiaRisk lociHippocampal volumeRisk factorsGlobal cognitive functionGlobal cognitive declineMultiple risk lociSpecific cognitive domainsAPOE e4 alleleCardiovascular risk factorsMixed regression modelsAlzheimer’s disease risk lociIsrael DiabetesOlder adultsDiabetes-relatedRisk scoreMagnetic resonance imaging
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