1998
Immunofluorometrically determined p53 accumulation as a prognostic indicator in italian breast cancer patients
Levesque M, Katsaros D, Yu H, Giai M, Genta F, Roagna R, Ponzone R, Massobrio M, Sismondi P, Diamandis E. Immunofluorometrically determined p53 accumulation as a prognostic indicator in italian breast cancer patients. International Journal Of Cancer 1998, 79: 147-152. PMID: 9583729, DOI: 10.1002/(sici)1097-0215(19980417)79:2<147::aid-ijc9>3.0.co;2-t.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnalysis of VarianceAntibody SpecificityBreast NeoplasmsCarcinoma, Ductal, BreastCombined Modality TherapyDisease-Free SurvivalFemaleFluorescent Antibody TechniqueHumansLymphatic MetastasisMiddle AgedMultivariate AnalysisNeoplasm StagingPredictive Value of TestsPrognosisReceptors, EstrogenReceptors, ProgesteroneRecurrenceSensitivity and SpecificityTime FactorsTumor Suppressor Protein p53ConceptsP53 proteinItalian breast cancer patientsProgesterone receptor expression statusMultivariate Cox regression analysisP53-negative patientsP53-positive patientsReceptor expression statusDisease-free survivalLymph node statusSteroid hormone receptor analysisCox regression analysisBreast cancer patientsEstrogen receptor expressionHormone receptor analysisCM-1 antibodySensitive immunofluorometric assayBreast cancer prognosisP53 protein accumulationOverall survivalPatient ageIndependent predictorsHistologic typeNode statusPrognostic valueShort patients
1994
p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients.
Zeng Z, Sarkis A, Zhang Z, Klimstra D, Charytonowicz E, Guillem J, Cordon-Cardo C, Cohen A. p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients. Journal Of Clinical Oncology 1994, 12: 2043-50. PMID: 7931472, DOI: 10.1200/jco.1994.12.10.2043.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoembryonic AntigenCell NucleusColorectal NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesGenes, p53HumansImmunohistochemistryLymph NodesLymphatic MetastasisMaleMiddle AgedMultivariate AnalysisPrognosisProportional Hazards ModelsTumor Suppressor Protein p53ConceptsColorectal cancer patientsNuclear p53 overexpressionP53 overexpressionCancer patientsPrimary tumorCarcinoembryonic antigenPreoperative serum carcinoembryonic antigenIndependent predictor of survivalP53 nuclear proteinP53-negative groupP53-positive patientsP53 nuclear stainingP53-negative patientsPreoperative CEA levelDisease-specific survivalMedian Follow-UpP53 nuclear overexpressionSerum carcinoembryonic antigenPatients died of colorectal cancerMonoclonal antibody PAbVascular vessel invasionPredictors of survivalP53 gene overexpressionFollow-up dataColorectal mucosal cells
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