p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients.
Zeng Z, Sarkis A, Zhang Z, Klimstra D, Charytonowicz E, Guillem J, Cordon-Cardo C, Cohen A. p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients. Journal Of Clinical Oncology 1994, 12: 2043-50. PMID: 7931472, DOI: 10.1200/jco.1994.12.10.2043.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoembryonic AntigenCell NucleusColorectal NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesGenes, p53HumansImmunohistochemistryLymph NodesLymphatic MetastasisMaleMiddle AgedMultivariate AnalysisPrognosisProportional Hazards ModelsTumor Suppressor Protein p53ConceptsColorectal cancer patientsNuclear p53 overexpressionP53 overexpressionCancer patientsPrimary tumorCarcinoembryonic antigenPreoperative serum carcinoembryonic antigenIndependent predictor of survivalP53 nuclear proteinP53-negative groupP53-positive patientsP53 nuclear stainingP53-negative patientsPreoperative CEA levelDisease-specific survivalMedian Follow-UpP53 nuclear overexpressionSerum carcinoembryonic antigenPatients died of colorectal cancerMonoclonal antibody PAbVascular vessel invasionPredictors of survivalP53 gene overexpressionFollow-up dataColorectal mucosal cells
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