2024
A pilot study of p53 immunohistochemistry in atypical squamous lesions, using a vulvar scoring system
Niu N, Roy S, Ko C. A pilot study of p53 immunohistochemistry in atypical squamous lesions, using a vulvar scoring system. Journal Of Cutaneous Pathology 2024, 51: 379-386. PMID: 38317537, DOI: 10.1111/cup.14591.Peer-Reviewed Original ResearchCutaneous squamous cell carcinomaLow-risk cSCCAtypical squamous lesionsSquamous lesionsP53 positivityHigh-risk cutaneous squamous cell carcinomaP53 labelingDiagnosis of cutaneous squamous cell carcinomaPattern of p53 mutationsScoring systemBenign squamous lesionsHigh-risk featuresSquamous cell carcinomaImmunohistochemical scoring systemVulvar casesP53 immunostainingBenign mimicsP53 immunohistochemistryCell carcinomaP53 mutationsTP53 sequencingHistopathologic overlapPilot studyCutaneous casesLesions
2017
GRB7 Expression and Correlation With HER2 Amplification in Invasive Breast Carcinoma
Bivin W, Yergiyev O, Bunker M, Silverman J, Krishnamurti U. GRB7 Expression and Correlation With HER2 Amplification in Invasive Breast Carcinoma. Applied Immunohistochemistry & Molecular Morphology 2017, 25: 553-558. PMID: 26945445, DOI: 10.1097/pai.0000000000000349.Peer-Reviewed Original ResearchConceptsInvasive breast carcinomaHER2 amplificationHER2 overexpressionER negativityPathologic stageHistologic gradeP53 positivityGRB7 expressionBreast cancerBreast carcinomaInvasive breast cancer correlatesInvasive breast cancerBreast cancer correlatesChromosome 17 copy numberAntiestrogen therapyPR expressionPredictive factorsHER2 expressionCancer correlatesPR testingP53 immunohistochemistryAggressive phenotypeHER2 geneHER2P53 status
2011
p53 Expression in Node-Positive Breast Cancer Patients: Results from the Cancer and Leukemia Group B 9344 Trial (159905)
Lara JF, Thor AD, Dressler LG, Broadwater G, Bleiweiss IJ, Edgerton S, Cowan D, Goldstein LJ, Martino S, Ingle JN, Henderson IC, Norton L, Winer EP, Hudis CA, Ellis MJ, Berry DA, Hayes DF, B F. p53 Expression in Node-Positive Breast Cancer Patients: Results from the Cancer and Leukemia Group B 9344 Trial (159905). Clinical Cancer Research 2011, 17: 5170-5178. PMID: 21693655, PMCID: PMC3149770, DOI: 10.1158/1078-0432.ccr-11-0484.Peer-Reviewed Original ResearchConceptsAddition of paclitaxelDoses of doxorubicinOverall survivalP53 protein expressionAdjuvant doxorubicinDose escalationBreast cancerP53 expressionNode-positive breast cancer patientsNode-positive breast cancerEarly-stage breast cancerCycles of cyclophosphamideNode-positive patientsProtein expressionStage II patientsBreast cancer patientsRandomized clinical trialsWorse RFSWorse OSII patientsPredictive factorsWorse prognosisCancer patientsP53 positivityP53 stainingCorrelation of Immunohistochemical Expression of p53 With Unamplified Chromosome 17 Polysomy in Invasive Breast Carcinoma
Krishnamurti U, Zarineh A, Atem F, Silverman J. Correlation of Immunohistochemical Expression of p53 With Unamplified Chromosome 17 Polysomy in Invasive Breast Carcinoma. Applied Immunohistochemistry & Molecular Morphology 2011, 19: 28-32. PMID: 20823770, DOI: 10.1097/pai.0b013e3181e9bb6f.Peer-Reviewed Original ResearchConceptsInvasive breast carcinomaChromosome 17 polysomyBreast carcinomaHER2 amplificationReceptor negativityPrognostic indicatorNottingham scoreBreast cancerNeck squamous cell carcinomaNonsmall cell lung carcinomaHormone receptor negativityAdverse prognostic indicatorEstrogen receptor negativitySquamous cell carcinomaIndependent prognostic indicatorCell lung carcinomaCell carcinomaP53 positivityBladder carcinomaP53 immunostainingP53 overexpressionImmunohistochemical expressionLung carcinomaCarcinomaP53 expression
1995
Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancer
Zhang Z, Zeng Z, Sarkis A, Klimstra D, Charytonowicz E, Pollack D, Vena J, Guillem J, Marshall J, Cordon-Cardo C, Cohen A, Begg C. Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancer. British Journal Of Cancer 1995, 71: 888-893. PMID: 7710960, PMCID: PMC2033726, DOI: 10.1038/bjc.1995.171.Peer-Reviewed Original ResearchConceptsFamily history of cancerHistory of cancerOdds ratioGenetic predisposition to colorectal cancerPredisposition to colorectal cancerFamily historyOccupational physical activityColorectal cancerMemorial Sloan-Kettering Cancer CenterDukes' C colorectal cancerFirst-degree relativesP53 overexpressionPhysical activityC colorectal cancerLowest quartileAetiological pathwaysCancer CenterAetiological heterogeneityQuartileP53-positive phenotypeP53 nuclear overexpressionMonoclonal antibody PAbBody weightP53 positivityTP53 mutations
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