Depletion of effector regulatory T cells associates with major response to induction dual immune checkpoint blockade.
Jiang X, Rudqvist N, Jiang B, Ye S, He S, Liang Q, Dou J, Williams M, Dunn J, Johnson J, Akagi K, Xiao W, Liang S, Elayavalli S, Sun B, Parra E, Ferrarotto R, Garden A, Fuller C, Reddy J, Gross N, Lango M, Leung C, Liu S, Liu D, Li M, Lee J, Curran M, Phan J, Chen K, Gillison M. Depletion of effector regulatory T cells associates with major response to induction dual immune checkpoint blockade. Cancer Discovery 2025, of1-of24. PMID: 40249124, DOI: 10.1158/2159-8290.cd-24-1390.Peer-Reviewed Original ResearchTissue-resident memoryCD8+ T cell clonotypesIntratumoral CD8+ T cellsComplete metabolic response rateDual immune checkpoint blockadeCD8+ T cellsResponse rateAnti-PD-1Concurrent with radiotherapyHistopathological response rateMetabolic response rateOropharyngeal carcinoma patientsAnti-CTLA-4Immune checkpoint blockadeProgression-free survivalPhase 2 trialT cell clonotypesCo-primary endpointsCheckpoint blockadeEffector memoryInduction immunotherapyTumor-reactiveRegulatory TTumor viabilityCarcinoma patients
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