O-077 EXPOSOME CHARACTERIZATION OF DIESEL ENGINE EXHAUST EXPOSURE
Lan Q, Vermeulen R, Rahman M, Dai Y, Hu W, Irving B, Lin X, Blechter B, Chaoyang D, Duan H, Wong J, Niu Y, Xu J, Chaoyang W, Meliefste K, Hosgood D, Ye M, Jia X, Meng T, Bin P, Silverman D, Zheng Y, Rothman N, Walker D. O-077 EXPOSOME CHARACTERIZATION OF DIESEL ENGINE EXHAUST EXPOSURE. Occupational Medicine 2024, 74: 0-0. DOI: 10.1093/occmed/kqae023.0598.Peer-Reviewed Original ResearchMetabolome-wide association studyAssociated with increased lung cancer riskHigh-resolution mass spectrometryAssociated with tumor developmentLung cancer riskMetabolic pathway enrichmentMolecular mechanismsTumor developmentCancer riskUrine mutagenicityEndothelial pathwaysUrinary mutagenicityLC-HRMSPlasma samplesMetabolic featuresGene expression analysisPlasma proteomePotential molecular mechanismsUntargeted analysisBiological alterationsMolecular featuresOxidative stressGenome-wide gene expressionBiological response profilesResponse profilesLeukocyte-associated immunoglobulin-like receptor-1 blockade in combination with programmed death-ligand 1 targeting therapy mediates increased tumour control in mice
Singh A, Mommers-Elshof E, Vijver S, Jansen J, Gonder S, Lebbink R, Bihan D, Farndale R, Boon L, Langermann S, Leusen J, Flies D, Meyaard L, Pascoal Ramos M. Leukocyte-associated immunoglobulin-like receptor-1 blockade in combination with programmed death-ligand 1 targeting therapy mediates increased tumour control in mice. Cancer Immunology, Immunotherapy 2024, 73: 16. PMID: 38236251, PMCID: PMC10796629, DOI: 10.1007/s00262-023-03600-6.Peer-Reviewed Original ResearchConceptsLeukocyte-associated immunoglobulin-like receptor-1Increase tumor controlTumor controlAnti-programmed death-ligand 1Mouse modelT cells in vitroMouse T cells in vitroIncreased tumor clearanceAnti-tumor responsesDeath-ligand 1Immunocompetent mouse modelReduced tumor burdenControl tumor growthHumanized mouse modelIn vivo tumor modelsWild type miceAssociated with tumor developmentPD-L1Tumor burdenTumor clearanceConventional immunotherapyImmunocompetent miceTumor outgrowthTherapy responseTumor microenvironment
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