2023
Lead induced differences in bone properties in osteocalcin +/+ and −/− female mice
Yildirim G, Budell W, Berezovska O, Yagerman S, Maliath S, Mastrokostas P, Tommasini S, Dowd T. Lead induced differences in bone properties in osteocalcin +/+ and −/− female mice. Bone Reports 2023, 18: 101672. PMID: 37064000, PMCID: PMC10090701, DOI: 10.1016/j.bonr.2023.101672.Peer-Reviewed Original ResearchBone strengthMineral/matrixBone remodelingHigher blood lead levelsSerum turnover markersLow lead exposureMajor health problemBlood lead levelsRole of osteocalcinBV/TVBone mineral propertiesTurnover markersFracture riskFemale miceLead exposureHealth problemsEffects of leadLead levelsBone formationCollagen maturityCross-sectional areaOsteocalcinLead toxicityBone propertiesBiomechanical measurements
2019
Mediation of the Acute Stress Response by the Skeleton
Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Yadav V, Rahmouni K, Gao XB, Karsenty G. Mediation of the Acute Stress Response by the Skeleton. Cell Metabolism 2019, 30: 890-902.e8. PMID: 31523009, PMCID: PMC6834912, DOI: 10.1016/j.cmet.2019.08.012.Peer-Reviewed Original ResearchConceptsStress responseBony vertebratesAcute stress responseBone-derived signalsWild-type animalsGenetic studiesEndocrine mediationAdrenal insufficient patientsVertebratesOsteocalcinSympathetic toneParasympathetic neuronsWildOsteocalcin levelsStressorsTypes of stressorsSelective surgeOsteoblastsInactivationRodentsResponseGlutamateUptake
2013
Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty G. Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions. Cell 2013, 155: 228-241. PMID: 24074871, PMCID: PMC3864001, DOI: 10.1016/j.cell.2013.08.042.Peer-Reviewed Original ResearchConceptsOsteoblast-derived hormone osteocalcinBrain developmentBone-derived signalsBlood-brain barrierFetal brain developmentInfluences brain developmentBone massNeuronal apoptosisMonoamine neurotransmittersGABA synthesisMemory deficitsNeuroanatomical defectsOffspring poolPostnatal functionMaternal genotypeMetabolic functionsOsteocalcinPowerful regulationBrainMaternal influenceRegulationBrainstemPregnancyHippocampusMidbrain
2007
Induction of a program gene expression during osteoblast differentiation with strontium ranelate
Zhu L, Zaidi S, Peng Y, Zhou H, Moonga B, Blesius A, Dupin-Roger I, Zaidi M, Sun L. Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Biochemical And Biophysical Research Communications 2007, 355: 307-311. PMID: 17300752, DOI: 10.1016/j.bbrc.2007.01.120.Peer-Reviewed Original ResearchConceptsStrontium ranelateBone sialoproteinCFU-OBEffects of strontium ranelateOsteoblast differentiationTreatment of osteoporosisGene expressionConcentration-dependent increaseStimulate bone formationColony-forming unit-osteoblastsBone marrow-derived stromal cellsMarrow-derived stromal cellsExpression of Runx2Increased osteoblast differentiationRanelateProgram of gene expressionStromal cellsPre-osteoblast cellsCell type-specificOB-6 cellsBone formationExperimental modelOsteocalcinProgrammed gene expressionType-specific
1998
Osteocalcin Production in Primary Osteoblast Cultures Derived from Normal and Hyp Mice
Carpenter T, Moltz K, Ellis B, Andreoli M, McCarthy T, Centrella M, Bryan D, Gundberg C. Osteocalcin Production in Primary Osteoblast Cultures Derived from Normal and Hyp Mice. Endocrinology 1998, 139: 35-43. DOI: 10.1210/en.139.1.35.Peer-Reviewed Original ResearchExposure to 1,25(OH)2D3Hyp micePrimary osteoblast culturesOsteoblast culturesOsteocalcin productionHuman X-linked hypophosphatemiaMurine osteoblastsMaturation-dependent fashionOsteocalcin messenger RNAHyp mouse modelEffects of 1,25(OH)2D3Response to 1,25(OH)2D3X-linked hypophosphatemiaMessenger RNASpecies-specific effectsInhibit osteoblast differentiationRegulation of osteocalcinMurine culturesIn vivo milieuMutant strainPrimary culturesStimulate osteocalcinDay 9MiceOsteocalcin
1996
Osteocalcin abnormalities in Hyp mice reflect altered genetic expression and are not due to altered clearance, affinity for mineral, or ambient phosphorus levels
Carpenter T, Gundberg C. Osteocalcin abnormalities in Hyp mice reflect altered genetic expression and are not due to altered clearance, affinity for mineral, or ambient phosphorus levels. Endocrinology 1996, 137: 5213-5219. DOI: 10.1210/en.137.12.5213.Peer-Reviewed Original ResearchDoses of 1,25-(OH)2D3Hyp miceCirculating osteocalcinNormal animalsIncreased serum osteocalcin levelsOsteocalcin mRNAResponse to 1,25-dihydroxyvitamin D3Response to 1,25-(OH)2D3Serum osteocalcin levelsC57 BL/6 miceDietary phosphorus deprivationRenal wastingOsteocalcin levelsDaily doseSingle doseBL/6 miceCirculating LevelsParadoxical decreaseAffinity of osteocalcinU-calciumBone osteocalcinMiceOsteocalcinOsteocalcin productionClearance
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