Clinical characteristics and outcomes of EZH2-mutant myelodysplastic syndrome: A large single institution analysis of 1774 patients
Ball S, Aguirre L, Jain A, Ali N, Tinsley S, Chan O, Kuykendall A, Sweet K, Lancet J, Sallman D, Hussaini M, Padron E, Komrokji R. Clinical characteristics and outcomes of EZH2-mutant myelodysplastic syndrome: A large single institution analysis of 1774 patients. Leukemia Research 2022, 124: 106999. PMID: 36542963, DOI: 10.1016/j.leukres.2022.106999.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeMedian OSEZH2 mutationsAssociated with inferior median OSAssociated with significantly worse OSMedian OS of patientsSingle-center retrospective studyInferior median OSIPSS-R categoryOS of patientsChromosome 7 abnormalitiesMoffitt Cancer CenterCo-occurring mutationsDeterminants of outcomeEZH2-mutationHypomethylating agentsRUNX1 mutationsMyeloid neoplasmsClinical characteristicsRetrospective studyClinical trialsCancer CenterPatientsImprove outcomesASXL1
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