2022
Lateralized Supraspinal Functional Connectivity Correlate with Pain and Motor Dysfunction in Rat Hemicontusion Cervical Spinal Cord Injury
Sanganahalli B, Pavuluri S, Chitturi J, Herman P, Elkabes S, Heary R, Hyder F, Kannurpatti S. Lateralized Supraspinal Functional Connectivity Correlate with Pain and Motor Dysfunction in Rat Hemicontusion Cervical Spinal Cord Injury. Neurotrauma Reports 2022, 3: 421-432. PMID: 36337081, PMCID: PMC9622206, DOI: 10.1089/neur.2022.0040.Peer-Reviewed Original ResearchMotor dysfunctionMotor networkCervical spinal cord injuryMotor functional recoverySpinal cord injuryFunctional connectivity correlatesSensory-motor integrationSupraspinal changesCervical SCIDeafferented sideSCI patientsUnaffected hemisphereFunctional recoverySupraspinal regionsClinical evidenceNociceptive activityCord injurySpinal cordLeft predominanceMaladaptive reorganizationRat modelPainConnectivity correlatesLarger painState fMRI
2018
Therapeutic potential of Pak1 inhibition for pain associated with cutaneous burn injury
Guo Y, Benson C, Hill M, Henry S, Effraim P, Waxman S, Dib-Hajj S, Tan AM. Therapeutic potential of Pak1 inhibition for pain associated with cutaneous burn injury. Molecular Pain 2018, 14: 1744806918788648. PMID: 29956587, PMCID: PMC6053256, DOI: 10.1177/1744806918788648.Peer-Reviewed Original ResearchConceptsDendritic spine dysgenesisNeuropathic painSpine dysgenesisBurn injurySignificant tactile allodyniaDorsal horn neuronsChronic disease burdenActivity-dependent expressionCutaneous burn injurySecond-degree burn injuryBurn injury modelC-fos expressionPotential molecular targetsDrug discontinuationHeat hyperalgesiaTactile allodyniaDorsal hornPain outcomesChronic painNociceptive activityLower painDisease burdenInjury modelCognitive dysfunctionPain
1996
Chapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat
LaMotte R, Zhang J, Petersen M. Chapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat. Progress In Brain Research 1996, 110: 105-111. PMID: 9000719, DOI: 10.1016/s0079-6123(08)62568-6.Peer-Reviewed Original ResearchConceptsDorsal root gangliaSensory neuronsIntact neuronsPartial peripheral nerve injuryDorsal root ganglion cellsChronic nerve constrictionPeripheral axonal injuryPeripheral nerve injuryPeripheral sensory neuronsPrimary sensory neuronsNerve constrictionNerve injuryAbnormal responsivenessAxonal injuryCollateral sproutingNeuropathological changesNociceptive activityDRG cellsRoot gangliaGanglion cellsSame nerveInjury siteUnmyelinated axonsAxonsNeurons
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