Early beta-blocker exposure and association with brain injury biomarkers following moderate to severe traumatic brain injury: A TRACK-TBI study.
Wongsripuemtet P, Ohnuma T, Temkin N, Barber J, Komisarow J, Manley G, Hatfield J, Treggiari M, Colton K, Sasannejad C, Chaikittisilpa N, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Miller J, Vavilala M, Goldstein B, Krishnamoorthy V. Early beta-blocker exposure and association with brain injury biomarkers following moderate to severe traumatic brain injury: A TRACK-TBI study. Journal Of The Intensive Care Society 2025, 17511437251349680. PMID: 40600218, PMCID: PMC12206746, DOI: 10.1177/17511437251349680.Peer-Reviewed Original ResearchNeuron-specific enolase levelsBeta-blocker exposureNeuron-specific enolaseUbiquitin C-terminal hydrolase-L1Beta-blockersC-reactive proteinBrain injury biomarkersIntensive care unitGlial fibrillary acidic proteinBiomarker levelsBB+ groupInjury biomarkersPrimary outcomeTraumatic brain injuryS100 calcium-binding protein BUCH-L1 levelsCalcium-binding protein BInflammatory biomarkers C-reactive proteinPropensity-weighted modelsRetrospective cohort studyPropensity-weighted analysisBiomarkers C-reactive proteinPotential neuroprotective effectsFibrillary acidic proteinRandomized Controlled Trials
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