2024
Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption
Ren P, Jiang B, Hassab A, Li G, Li W, Assi R, Tellides G. Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption. Arteriosclerosis Thrombosis And Vascular Biology 2024, 45: 260-276. PMID: 39697172, PMCID: PMC12053597, DOI: 10.1161/atvbaha.124.321706.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic AneurysmCell LineageDisease Models, AnimalGene Expression ProfilingHomeobox Protein Nkx-2.5HumansMaleMarfan SyndromeMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleMyosin Heavy ChainsNeural CrestPhenotypeReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaSignal TransductionSingle-Cell AnalysisTranscription, GeneticTranscriptomeTransforming Growth Factor betaWnt1 ProteinConceptsSmooth muscle cell clustersSmooth muscle cellsAortic smooth muscle cellsNeural crest-derived smooth muscle cellsCardiac derivativesMurine aortic smooth muscle cellsNeural crest originReceptor deletionAortic rootAdult miceNeural crest progenitorsNKX2-5Proximal aortaTranscriptional changesMouse modelTGFB signalingMuscle cellsConditional deletionAdult human aortaEmbryological originIncreased expressionAnalyzed single-cell transcriptomesTGFB receptorsBasal stateAortic homeostasis
2016
Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas
Toledo RA, Qin Y, Cheng ZM, Gao Q, Iwata S, Silva GM, Prasad M, Ocal IT, Rao S, Aronin N, Barontini M, Bruder J, Reddick RL, Chen Y, Aguiar RC, Dahia PL. Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. Clinical Cancer Research 2016, 22: 2301-2310. PMID: 26700204, PMCID: PMC4854762, DOI: 10.1158/1078-0432.ccr-15-1841.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenal Gland NeoplasmsAdultAgedc-Mer Tyrosine KinaseCarcinoma, NeuroendocrineChildChromatinChromatin Assembly and DisassemblyExomeFemaleGerm-Line MutationGiant Cell Tumor of BoneHistone DemethylasesHistone MethyltransferasesHistone-Lysine N-MethyltransferaseHistonesHumansMaleMiddle AgedParagangliomaPheochromocytomaThyroid NeoplasmsYoung AdultConceptsHistone methylation analysisAnalysis of mutantsChromatin-remodeling genesChromatin remodelingHistone demethylasesTranscriptome sequencingFrequent genetic eventKinase geneMolecular basisPPGL susceptibility genesGenesGenetic eventsNeural crest originMethylation analysisSusceptibility genesNew cancer syndromeMost PPGLsMutationsSomatic mutationsProtein expressionCell linesDomain mutationsFGFR1 mutationsWestern blottingDriver mutationsMelanotic neuroectodermal tumor of infancy
Wu X, Shankar S, Munday WR, Malhotra A. Melanotic neuroectodermal tumor of infancy. Journal Of Clinical Neuroscience 2016, 31: 205-207. PMID: 27095686, DOI: 10.1016/j.jocn.2016.02.023.Peer-Reviewed Original ResearchConceptsMelanotic neuroectodermal tumorNeuroectodermal tumorEvidence of recurrenceOld male patientComplete surgical excisionCharacteristic radiographic appearanceNeural crest originMale patientsSurgical excisionClinical findingsMagnetic resonance sequencesPreoperative diagnosisCraniofacial tumorsUnusual tumorFibrous stromaNeuroblastic cellsCT scanRadiographic appearanceBiphasic populationTumorsEarly childhoodResonance sequencesMNTIInfancyCells
1997
NaG: A sodium channel‐like mRNA shared by Schwann cells and other neural crest derivatives
Felts PA, Black JA, Dib‐Hajj S, Waxman SG. NaG: A sodium channel‐like mRNA shared by Schwann cells and other neural crest derivatives. Glia 1997, 21: 269-276. PMID: 9383036, DOI: 10.1002/(sici)1098-1136(199711)21:3<269::aid-glia2>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsNeural crest originSchwann cellsGanglion neuronsNeural crest derivativesRat dorsal root ganglion neuronsAdrenal medulla chromaffin cellsDorsal root ganglion neuronsSuperior cervical ganglion neuronsSodium channelsCrest derivativesNeural crestNeuronal cell typesAfferent neuronsAfferent functionSitu hybridizationSensory neuronsNeural elementsSensory functionChromaffin cellsNAG mRNANeuronsRT-PCRNAGCell typesPresent study
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