Pigment epithelium-derived factor engineered to increase glycosaminoglycan affinity while maintaining bioactivity
Chu H, Rebustini I, Becerra S, Wang Y. Pigment epithelium-derived factor engineered to increase glycosaminoglycan affinity while maintaining bioactivity. Biochemical And Biophysical Research Communications 2022, 605: 148-153. PMID: 35334413, PMCID: PMC11371396, DOI: 10.1016/j.bbrc.2022.03.079.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorEpithelium-derived factorNegatively charged extracellular matrixInhibit endothelial cell proliferationAmino acid sequenceHyaluronic acidEndothelial cell proliferationExtracellular matrixRetinal degenerationRetinal diseasesRetinal microenvironmentProtect photoreceptorsTherapeutic effectVitreous humorProtein engineeringGlycosaminoglycan affinitySecreted proteinsTherapeutic drugsTube formationTissue homeostasisCell deathCell proliferationEfficient therapeutic drugsCationic residuesBinding assays
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