Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study
Chan K, Wahome E, Tsiachristas A, Antonopoulos A, Patel P, Lyasheva M, Kingham L, West H, Oikonomou E, Volpe L, Mavrogiannis M, Nicol E, Mittal T, Halborg T, Kotronias R, Adlam D, Modi B, Rodrigues J, Screaton N, Kardos A, Greenwood J, Sabharwal N, De Maria G, Munir S, McAlindon E, Sohan Y, Tomlins P, Siddique M, Kelion A, Shirodaria C, Pugliese F, Petersen S, Blankstein R, Desai M, Gersh B, Achenbach S, Libby P, Neubauer S, Channon K, Deanfield J, Antoniades C, Consortium O, Thomas S, Denton J, Farral R, Taylor C, Qin W, Kasongo M, Anthony S, Banning A, Xie C, Kharbanda R, Pritchard A, Halborg T, Syed N, Fry S, Mathers C, Rose A, Hudson G, Bajaj A, Das I, Deshpande A, Rao P, Lawday D, Mirsadraee S, Hudson B, Berry C, Marwan M, Maurovich-Horvat P, He G, Lin W, Fan L, Takahashi N, Kondo H, Dai N, Ge J, Koo B, Guglielmo M, Pontone G, Huck D, Benedek T, Rajani R, Vilic D, Aljazzaf H, Mun M, Benedetti G, Preston R, Raisi-Estabragh Z, Connolly D, Sharma V, Grenfell R, Bradlow W, Schmitt M, Serfaty F, Gottlieb I, Neves M, Newby D, Dweck M, Hatem S, Redheuil A, Benetos G, Beer M, Granillo G, Selvanayagam J, Lopez-Jimenez F, De Bosscher R, Tavildari A, Figtree G, Danad I, Shantouf R, Kietselaer B, Tousoulis D, Dangas G, Mehta N, Kontanidis C, Kunadian V, Fairbairn T. Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study. The Lancet 2024, 403: 2606-2618. PMID: 38823406, PMCID: PMC11664027, DOI: 10.1016/s0140-6736(24)00596-8.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary Computed Tomography AngiographyFat attenuation indexCoronary artery diseaseCardiac mortalityNational Health ServiceLongitudinal cohort studyConsecutive patientsRisk factorsPrognostic valueYears median follow-up periodAbsence of obstructive coronary artery diseaseCohort studyArtery diseaseInflammatory riskMedian follow-up periodAssociated with cardiac mortalityPerivascular fat attenuation indexCoronary arteryExtent of coronary artery diseaseTotal cardiac deathClinical risk stratificationAdverse cardiac eventsNational Institute for Health and Care ResearchClinical risk factors
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