Disruption of the with no lysine kinase–STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II
Cervantes-Perez L, Castaneda-Bueno M, Jimenez J, Vazquez N, Rojas-Vega L, Alessi D, Bobadilla N, Gamba G. Disruption of the with no lysine kinase–STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II. Journal Of Hypertension 2017, 36: 361-367. PMID: 28877076, PMCID: PMC5757652, DOI: 10.1097/hjh.0000000000001554.Peer-Reviewed Original ResearchConceptsNa-Cl cotransporterKnock-In MiceEffects of AngIIHypertensive effectAngiotensin IIEpithelial sodium channel activityNa-Cl-cotransporter activityNCC phosphorylationRenal Na-Cl cotransporterBlood pressureHypertensive effect of angiotensin IIEffects of angiotensin IIAldosterone-treated miceAlanine-rich kinaseAldosterone-induced hypertensionResponse to amilorideThiazide-type diureticsInduced arterial hypertensionEffects of aldosteroneAngII-induced hypertensionNaCl drinking waterSodium channel activityArterial blood pressureAngII infusionOsmotic minipumps
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