2025
Identification of Serum Metabolites to Improve Diagnostic Efficacy in Pulmonary Embolism
Chen S, Xu X, Li X, Qin Q, Zhu G, Yu H, Du K, Wang X, Ye W, Gu W. Identification of Serum Metabolites to Improve Diagnostic Efficacy in Pulmonary Embolism. Journal Of Proteome Research 2025, 24: 1885-1894. PMID: 40128110, DOI: 10.1021/acs.jproteome.4c00863.Peer-Reviewed Original ResearchConceptsGas chromatography-mass spectrometryPulmonary embolismDiagnostic efficacyHigh-throughput metabolomics methodPE patientsValidation cohortSerum metabolic profilesUnsupervised principal component analysisDiscovery cohortMetabolic profileHealthy individualsChromatography-mass spectrometryD-dimer levelsMetabolomics methodMultivariate data analysisPLS-DALife-threatening diseaseD-dimerClinical indicationsHealthy controlsBiomarker panelEmbolizationSerum metabolitesCohortPotential biomarkers
2021
Conditional score matching for high-dimensional partial graphical models
Fan X, Zhang Q, Ma S, Fang K. Conditional score matching for high-dimensional partial graphical models. Computational Statistics & Data Analysis 2021, 153: 107066. DOI: 10.1016/j.csda.2020.107066.Peer-Reviewed Original ResearchConditional scoreComputational complexityMore general distributionsEffective computational algorithmGraphical modelsStatistical propertiesHigh computational costPartial graphsComputational algorithmComputational costNormalization constantsBreast cancer gene expression datasetsGeneral distributionNetwork constructionCancer gene expression datasetsMultiplicative normalizationMultivariate data analysisGene expression datasetsCompetitive performanceComplexityGraphData analysisModelConstruction approachExpression datasets
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