2025
FlgY, PflA, and PflB form a spoke–ring network in the high-torque flagellar motor of Helicobacter pylori
Tachiyama S, Rosinke K, Khan M, Zhou X, Xin Y, Botting J, Yue J, Roujeinikova A, Hoover T, Liu J. FlgY, PflA, and PflB form a spoke–ring network in the high-torque flagellar motor of Helicobacter pylori. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2421632122. PMID: 40261933, PMCID: PMC12054838, DOI: 10.1073/pnas.2421632122.Peer-Reviewed Original ResearchConceptsMS ringAccessory proteinsStator complexWild-type <i>H. pyFlagellar motorSalmonella enterica</i>Protein-protein interactionsFlagellar motilityAlphaFold-predicted structuresFlgIBiochemical approachesPflBGastric mucus layerMolecular geneticsPFLACryoelectron tomographyUnique motilityBacterial flagellar motorMucus layerMotilityBacteriaProteinHuman stomachPseudoatomic modelHelicobacter pylori
2019
Loss of a Cardiolipin Synthase in Helicobacter pylori G27 Blocks Flagellum Assembly
Chu JK, Zhu S, Herrera CM, Henderson JC, Liu J, Trent MS, Hoover TR. Loss of a Cardiolipin Synthase in Helicobacter pylori G27 Blocks Flagellum Assembly. Journal Of Bacteriology 2019, 201: 10.1128/jb.00372-19. PMID: 31427391, PMCID: PMC6779456, DOI: 10.1128/jb.00372-19.Peer-Reviewed Original ResearchConceptsFlagellum assemblyFlagellum biosynthesisCardiolipin synthaseFlagellar protein export apparatusCardiolipin levelsProtein export apparatusCryo-electron tomographyWild-type levelsAllelic exchange mutagenesisMS ringFlagellar genesExport apparatusCell polesP ringHost colonizationMature flagellumCell envelopeGenomic DNAMutantsProximal rodFlagellaBiosynthesisSequencing analysisFlgIBacterial pathogens
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