2012
Statins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis
Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. Statins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis. Reproductive Sciences 2012, 19: 572-579. PMID: 22267540, PMCID: PMC3439122, DOI: 10.1177/1933719111430998.Peer-Reviewed Original ResearchConceptsCultured endometriotic cellsMonocyte chemotactic protein-1 expressionChemotactic protein-1 expressionMCP-1 productionEndometriotic cellsProtein-1 expressionEndometriotic implantsMouse modelMCP-1 messenger RNA expressionExerts anti-inflammatory effectsAnti-inflammatory effectsEffect of statinsAnti-inflammatory propertiesMCP-1 expressionMevalonate pathwayDose-dependent inhibitionNude mouse modelMessenger RNA expressionDose-dependent mannerEctopic endometriumEndometrial cellsPeritoneal surfaceStatinsPotential treatmentInhibitory effect
2002
Estradiol suppresses vascular monocyte chemotactic protein-1 expression during early atherogenesis
Seli E, Kayisli UA, Selam B, Seli M, Arici A. Estradiol suppresses vascular monocyte chemotactic protein-1 expression during early atherogenesis. American Journal Of Obstetrics And Gynecology 2002, 187: 1544-1549. PMID: 12501061, DOI: 10.1067/mob.2002.127306.Peer-Reviewed Original ResearchConceptsMonocyte chemotactic protein-1 expressionChemotactic protein-1 expressionProtein-1 expressionLipid depositionSerum total cholesterol concentrationVascular lipid depositionProtein 1 antibodyAorta of animalsTotal cholesterol concentrationDevelopment of atherosclerosisSmooth muscle cellsPlacebo pelletsAtherogenic stimuliDeficient miceMacrophage recruitmentEarly atherogenesisImmunohistochemical analysisTreatment groupsC57BL/6 backgroundCholesterol concentrationsMuscle cellsArterial wallB stainingAortaEstradiol
2001
Estradiol fails to down-regulate monocyte chemotactic protein-1 (MCP-1) expression in endometrial cells of women with endometriosis.
Arici A, Bahtiyar M, Seli E, Senturk L. Estradiol fails to down-regulate monocyte chemotactic protein-1 (MCP-1) expression in endometrial cells of women with endometriosis. Fertility And Sterility 2001, 76: s47. DOI: 10.1016/s0015-0282(01)02155-0.Peer-Reviewed Original ResearchMonocyte chemotactic protein-1 expressionChemotactic protein-1 expressionProtein-1 expressionEndometrial cellsEndometriosisEstradiol
1999
Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1
Garcia-Velasco J, Seli E, Arici A. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1. Biology Of Reproduction 1999, 61: 548-552. PMID: 10411539, DOI: 10.1095/biolreprod61.2.548.Peer-Reviewed Original ResearchConceptsCell adhesionExtracellular matrix connectionsActin cytoskeletonMCP-1 regulationGene expressionIntegrin activationECM substratesProtein secretionStromal cell adhesionCytochalasin DCell typesMCP-1 gene expressionNovel mechanismHuman endometrial stromal cellsMonocyte chemotactic protein-1 expressionProtein levelsIntegrinsProtein-1 expressionAdhesion matrixRegulationExpressionStromal cellsESC adhesionEndometrial stromal cellsCollagen IVRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1
Arici A, Senturk L, Seli E, Bahtiyar M, Kim G. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1. Biology Of Reproduction 1999, 61: 85-90. PMID: 10377035, DOI: 10.1095/biolreprod61.1.85.Peer-Reviewed Original ResearchConceptsMCP-1 expressionEndometrial stromal cellsHuman endometrial stromal cellsMCP-1 levelsStromal cellsMacrophage migrationEstrogen levelsMCP-1 protein productionMonocyte chemotactic protein-1 expressionMCP-1 mRNA levelsChemotactic protein-1 expressionChemotactic protein-1Combination of E2Steroid hormone levelsProtein-1 expressionConcentration-dependent mannerEndometrial macrophagesMCP-1E2 treatmentHormone levelsSex steroidsEstradiol-17betaProgesteroneMRNA levelsProtein 1
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