Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis
Goetzl EJ, Srihari VH, Guloksuz S, Ferrara M, Tek C, Heninger GR. Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis. The FASEB Journal 2021, 35: e21339. PMID: 33454965, DOI: 10.1096/fj.202002519r.Peer-Reviewed Original ResearchMeSH KeywordsAdultAstrocytesDNA-Binding ProteinsExosomesFemaleGTP PhosphohydrolasesHumansIntracellular Signaling Peptides and ProteinsMaleMitochondriaMitochondrial ProteinsMitochondrial Proton-Translocating ATPasesMyosin Heavy ChainsNeuronsPeptidyl-Prolyl Isomerase FPsychotic DisordersTranscription FactorsConceptsNeuron-derived extracellular vesiclesFunctional proteinsMitochondrial functional proteinsMitochondrial protein mitofusin 2Extracellular vesiclesMitochondrial ATP synthaseMitochondrial ATP synthase activityATP synthase activityTranscription factor AMitochondrial proteinsATP synthaseMyosin VICyclophilin DConversion of NADHMitofusin 2EV contentExosome markersPeptide humaninProteinMitochondrial impairmentSynthase activityProtein levelsFactor AMitochondriaVesicles
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