2025
Structure of mitochondrial pyruvate carrier and its inhibition mechanism
He Z, Zhang J, Xu Y, Fine E, Suomivuori C, Dror R, Feng L. Structure of mitochondrial pyruvate carrier and its inhibition mechanism. Nature 2025, 641: 250-257. PMID: 40044865, PMCID: PMC12043432, DOI: 10.1038/s41586-025-08667-y.Peer-Reviewed Original ResearchConceptsMitochondrial pyruvate carrierPyruvate carrierMPC functionSubstrate-binding siteCytosolic glycolysisCentral metaboliteTranslocation pathwayCellular metabolismMolecular basisMetabolic gatekeeperMolecular mechanismsConformational statesInhibition mechanismTherapeutic reagentsTransport functionCritical roleStructural findingsNon-alcoholic steatohepatitisInhibitionTranslocationGlycolysisPathwayBindingMetabolismPhysiology
2022
UCP2-dependent redox sensing in POMC neurons regulates feeding
Yoon N, Jin S, Kim J, Liu Z, Sun Q, Cardone R, Kibbey R, Diano S. UCP2-dependent redox sensing in POMC neurons regulates feeding. Cell Reports 2022, 41: 111894. PMID: 36577374, PMCID: PMC9885759, DOI: 10.1016/j.celrep.2022.111894.Peer-Reviewed Original ResearchConceptsPOMC neuronsGlucose metabolismPOMC neuronal activityAnorexigenic pro-opiomelanocortin (POMC) neuronsPro-opiomelanocortin (POMC) neuronsHigh-fat dietFatty acid metabolismMitochondrial respirationLactate levelsCerebrospinal fluidNeuronal activityGlucose utilizationFed stateNeuronsPyruvate levelsExtracellular pyruvate levelsAcid metabolismMalate-aspartate shuttleMetabolismAddition of lactateMitochondrial pyruvate carrierInhibitionObesityPyruvate carrierSatiety
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