Refining colorectal cancer classification and clinical stratification through a single-cell atlas
Khaliq A, Erdogan C, Kurt Z, Turgut S, Grunvald M, Rand T, Khare S, Borgia J, Hayden D, Pappas S, Govekar H, Kam A, Reiser J, Turaga K, Radovich M, Zang Y, Qiu Y, Liu Y, Fishel M, Turk A, Gupta V, Al-Sabti R, Subramanian J, Kuzel T, Sadanandam A, Waldron L, Hussain A, Saleem M, El-Rayes B, Salahudeen A, Masood A. Refining colorectal cancer classification and clinical stratification through a single-cell atlas. Genome Biology 2022, 23: 113. PMID: 35538548, PMCID: PMC9092724, DOI: 10.1186/s13059-022-02677-z.Peer-Reviewed Original ResearchConceptsConsensus molecular subtypesTumor microenvironmentAssociated with immunotherapy resistanceCAF subtypesImmune checkpoint inhibitorsHuman CRC samplesIndependent external cohortMechanism of tumorsMSI-HContribution to pathogenesisResultsTumor cellsCheckpoint inhibitorsImmunotherapy resistanceImmunotherapy responseEpithelial levelClinicopathological characteristicsMolecular subtypesClinical stratificationCRC patientsMicroenvironmental cellsPatient prognosisPoor outcomeMSI-H CRCsBackgroundColorectal cancerColorectal cancer classification
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