Predictors of response to sequential sunitinib and the impact of prior VEGF-targeted drug washout in patients with metastatic clear-cell renal cell carcinoma
Elfiky A, Cho D, McDermott D, Rosenberg J, Fortner B, Antràs L, Chen K, Duh M, Jayawant S, Oh W, Atkins M, Choueiri T. Predictors of response to sequential sunitinib and the impact of prior VEGF-targeted drug washout in patients with metastatic clear-cell renal cell carcinoma. Urologic Oncology Seminars And Original Investigations 2010, 29: 756-763. PMID: 20451414, DOI: 10.1016/j.urolonc.2010.01.008.Peer-Reviewed Original ResearchConceptsProgression-free survivalSequential sunitinibOverall survivalBrain metastasesSequential therapyRCC patientsLow hemoglobinMetastatic clear-cell renal cell carcinomaMetastatic clear-cell RCC patientsMedian duration of follow-upClear-cell RCC patientsMedian progression-free survivalFactors associated with poor outcomeClear-cell renal cell carcinomaDuration of follow-upFailure of bevacizumabClear cell RCC patientsRenal cell carcinomaBaseline clinical variablesFailed sorafenibMedian OSShorter OSMedian durationCell carcinomaDrug washout
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