Aficamten Treatment for Symptomatic Obstructive Hypertrophic Cardiomyopathy 48-Week Results From FOREST-HCM
Saberi S, Abraham T, Choudhury L, Barriales-Villa R, Elliott P, Nassif M, Oreziak A, Owens A, Tower-Rader A, Rader F, Garcia-Pavia P, Olivotto I, Coats C, Fifer M, Sherrid M, Solomon S, Watkins H, Heitner S, Jacoby D, Kupfer S, Malik F, Melloni C, Meng L, Wei J, Maron M, Masri A, Committee and Investigators F. Aficamten Treatment for Symptomatic Obstructive Hypertrophic Cardiomyopathy 48-Week Results From FOREST-HCM. JACC Heart Failure 2025, 13: 102496. PMID: 40540987, DOI: 10.1016/j.jchf.2025.03.040.Peer-Reviewed Original ResearchLeft ventricular ejection fractionOutflow tract gradientVentricular ejection fractionEjection fractionKansas City Cardiomyopathy Questionnaire-Clinical Summary ScorePeak left ventricular outflow tract gradientLeft ventricular outflow tract gradientMaximum left ventricular wall thicknessSymptomatic obstructive hypertrophic cardiomyopathyLeft atrial volume indexWeeks of follow-upAtrial volume indexObstructive hypertrophic cardiomyopathyFunctional class improvementLeft ventricular wall thicknessBaseline to weekFavorable cardiac remodelingNYHA functional class improvementRelief of obstructionCardiac biomarker levelsVentricular wall thicknessLong-term safetyDrug discontinuationLateral E/eOpen-label
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